O,O'-双(2,2,2-三氟乙基)磷乙酸甲酯合成路线 （共 27 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=20°C; 16 h; Inert atmosphereCooling with ice;
参考文献
Messik, Frauke; Oberthuer, Markus
Synthesis (Germany), 2013 , vol. 45, # 2 art. no. SS-2012-T0771-PSP, p. 167 - 170
反应条件
N-ethyl-N,N-diisopropylamine 1.) in benzene, 0 deg C; 2.) 25 deg C, 1h; Yield given. Multistep reaction;
参考文献
Still, W. Clark; Gennari, Cesare
Tetrahedron Letters, 1983 , vol. 24, # 41 p. 4405 - 4408
反应条件
1: phosphonoacetic acid P,P-bis(2,2,2-trifluoroethyl)methyl ester With sodium hexamethyldisilazane; 18-crown-6 ether in tetrahydrofuran; toluene T=-70°C; 0.25 h; 2: trans,trans-2,4-octadienal in tetrahydrofuran; toluene T=-75°C; Horner-Wadsworth-Emmons olefination; 1 h;
参考文献
Khrimian, Ashot
Tetrahedron, 2005 , vol. 61, # 15 p. 3651 - 3657
反应条件
1: phosphonoacetic acid P,P-bis(2,2,2-trifluoroethyl)methyl ester With sodium hexamethyldisilazane; 18-crown-6 ether in tetrahydrofuran; toluene T=-70°C; 0.25 h; 2: trans,cis-2,4-octadienal in tetrahydrofuran; toluene T=-75°C; Horner-Wadsworth-Emmons olefination; 1 h;
参考文献
Khrimian, Ashot
Tetrahedron, 2005 , vol. 61, # 15 p. 3651 - 3657
反应条件
PLE Enzymatic reaction;
参考文献
Sano, Shigeki; Takemoto, Yuka; Nagao, Yoshimitsu
Tetrahedron Letters, 2003 , vol. 44, # 49 p. 8853 - 8855
反应条件
1-ethyl-piperidine; tin(II) trifluoromethanesulfonate in tetrahydrofuran T=-78°C; 20 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Sano, Shigeki; Yokoyama, Kenji; Fukushima, Mari; Yagi, Tetsuo; Nagao, Yoshimitsu
Chemical Communications, 1997 , # 6 p. 559 - 560
反应条件
1: With sodium hydride in ethylene glycol dimethyl ether T=20°C; 1 h; 2: With bromine in ethylene glycol dimethyl ether T=0 - 20°C; 2.25 h;
参考文献
Olpp, Thomas; Brueckner, Reinhard
Synthesis, 2004 , # 13 p. 2135 - 2152
反应条件
1: 85 percent / NaOH; Br2 / H2O 2: 70 percent / SnCl2*2H2O / aq. ethanol / 0.67 h / -25 °C View Scheme
参考文献
Tago, Keiko; Kogen, Hiroshi
Organic Letters, 2000 , vol. 2, # 13 p. 1975 - 1978
反应条件
1-ethyl-piperidine; tin(II) trifluoromethanesulfonate in dichloromethane T=0°C; 15 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Rossi, Daniela; Baraglia, Anna Carnevale; Serra, Massimo; Azzolina, Ornella; Collina, Simona
Molecules, 2010 , vol. 15, # 9 p. 5928 - 5942
反应条件
potassium hexamethylsilazane T=-78°C;
参考文献
Parker; Fokas
Journal of Organic Chemistry, 1994 , vol. 59, # 14 p. 3927 - 3932
