1-(3,4-二氢-2H-吡咯-5-基)-9H-beta-咔啉合成路线 （共 17 条）
反应条件
1: SOCl2
2: 74 percent / NaOH / H2O; CH2Cl2 / 1 h
3: 74 percent / PPE / CH2Cl2 / 0.83 h / Heating
4: 90 percent / DDQ / benzene / Ambient temperature
View Scheme
参考文献
Hino, Tohru; Lai, Ziping; Seki, Hiroko; Hara, Ritsuko; Kuramochi, Tadao; Nakagawa, Masako
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2596 - 2600
反应条件
1: 2.) AgBF4 / 1.) room temperature, 2.) -20 deg C
2: elementar sulfur / 0.07 h / 200 °C
3: hydrazine / methanol
View Scheme
参考文献
VanWagenen; Cardellina II
Tetrahedron Letters, 1989 , vol. 30, # 28 p. 3605 - 3608
反应条件
1: elementar sulfur / 0.07 h / 200 °C
2: hydrazine / methanol
View Scheme
参考文献
VanWagenen; Cardellina II
Tetrahedron Letters, 1989 , vol. 30, # 28 p. 3605 - 3608
反应条件
1: 2) TFA / 1) benzene, 15 min, 2) 12 h
2: 83 percent / O2 / CCl4 / 72 h / Heating
3: 86 percent / hydrazine / benzene; ethanol
View Scheme
参考文献
Wasserman, Harry H.; Kelly, Terence A.
Tetrahedron Letters, 1989 , vol. 30, # 50 p. 7117 - 7120
反应条件
1: 83 percent / O2 / CCl4 / 72 h / Heating
2: 86 percent / hydrazine / benzene; ethanol
View Scheme
参考文献
Wasserman, Harry H.; Kelly, Terence A.
Tetrahedron Letters, 1989 , vol. 30, # 50 p. 7117 - 7120
反应条件
1: 48 percent / trimethylsilyl iodide / CHCl3 / 0.25 h / Ambient temperature
2: 90 percent / DDQ / benzene / Ambient temperature
View Scheme
参考文献
Hino, Tohru; Lai, Ziping; Seki, Hiroko; Hara, Ritsuko; Kuramochi, Tadao; Nakagawa, Masako
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2596 - 2600
反应条件
N-bromosuccinmide in dichloromethane
0.75 h; Ambient temperature;
参考文献
Hino, Tohru; Lai, Ziping; Seki, Hiroko; Hara, Ritsuko; Kuramochi, Tadao; Nakagawa, Masako
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2596 - 2600
