3-甲基噻吩-2-硼酸频哪醇酯合成路线 （共 3 条）
反应条件
1: 2-bromo-3-methyl-thiophene With n-butyllithium in tetrahydrofuran; hexane T=-40°C; 0.5 h; 2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; hexane T=20°C; 1 h;
参考文献
Illig, Carl R.; Ballentine, Shelley K.; Chen, Jinsheng; Meegalla, Sanath K.; Rudolph, M. Jonathan; Wall, Mark J.; Wilson, Kenneth J.; Desjarlais, Renee L.; Manthey, Carl L.; Molloy, Christopher J.
Patent: US2008/51402 A1, 2008 ;
Location in patent: Page/Page column 35 ;
US 20080051402 A1
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-40 - 20°C; 1.5 h; 2: With sodium hydrogencarbonate in tetrahydrofuran; hexane; water T=0°C;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2007/48088 A2, 2007 ;
Location in patent: Page/Page column 61-62 ;
WO 2007/048088 A2
反应条件
4,4'-di(tert-butyl)-2,2'-dipyridyl; [Ir(μ2-OMe)(1,4-cyclooctadiene)]2 in hexane T=20°C; 1 h; Title compound not separated from byproducts.;
参考文献
Tetrahedron, , vol. 64, # 26 p. 6103 - 6114
