1H-吲唑-4-硼酸频哪醇酯合成路线 （共 15 条）
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in dimethyl sulfoxide T=80°C; 40 h; Product distribution / selectivity;
参考文献
Curis, Inc.; Bao, Rudi; Lai, Chengjung; Qian, Changgeng
Patent: US2013/102595 A1, 2013 ;
Location in patent: Paragraph 0173 ;
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in dimethyl sulfoxide T=80°C; 40 h; Product distribution / selectivity;
参考文献
WO2007/127183 A1, ;
Page/Page column 138 ;
WO 2007/127183 A1
反应条件
1: 1H-indazol-4-amine With hydrogenchloride; sodium nitrite in water T=0°C; 2: With sodium tetrafluoroborate in water 3: 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in methanol Suzuki Coupling; 5 h; Inert atmosphere;
参考文献
WO2009/146406 A1, ;
Page/Page column 65 ;
WO 2009/146406 A1
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in methanol T=20°C;
参考文献
SPHAERA PHARMA PVT. LTD.; DUGAR, Sundeep; MAHAJAN, Dinesh; HOLLINGER PETER, Frank; SHARMA, Amit; TRIPATHI, Vinayak; KUILA, Bilash
Patent: WO2014/16849 A2, 2014 ;
Location in patent: Page/Page column 112; 113 ;
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in dimethyl sulfoxide T=80°C; 40 h; Product distribution / selectivity;
参考文献
WO2007/132171 A1, ;
Page/Page column 42-43 ;
WO 2007/132171 A1
反应条件
1.1: potassium acetate / chloroform / 0.17 h / 20 °C / Cooling with ice 1.2: 18 h / Reflux 2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 40 h / 80 °C / Inert atmosphere View Scheme
参考文献
WO2011/130628 A1, ;
WO 2011/130628 A1
反应条件
1: hydrogen / palladium 10 on activated carbon / ethanol 2: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C 3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / methanol / 5 h / Inert atmosphere View Scheme
参考文献
WO2012/82997 A1, ;
WO 2012/082997 A1
反应条件
1: sodium nitrite / water; acetic acid / 15 - 30 °C 2: hydrogen / palladium 10 on activated carbon / ethanol 3: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C 4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / methanol / 5 h / Inert atmosphere View Scheme
参考文献
WO2012/82997 A1, ;
WO 2012/082997 A1
反应条件
1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C 2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / methanol / 5 h / Inert atmosphere View Scheme
参考文献
WO2012/82997 A1, ;
WO 2012/082997 A1
反应条件
1: hydrogenchloride / water; methanol / 7 h / 20 °C 2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 40 h / 80 °C / Inert atmosphere View Scheme
参考文献
WO2011/130628 A1, ;
WO 2011/130628 A1
