5-溴吡唑并[1,5-a]吡啶-3-羧酸乙酯合成路线 （共 5 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide 0.166667 h;
参考文献
3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.
Patent: WO2014/8197 A1, 2014 ;
Location in patent: Page/Page column 135 ;
反应条件
1.1: dichloromethane / 18 h / 20 °C 2.1: hydrogen bromide; sodium nitrite / water / 0.25 h / 0 °C 2.2: 0.25 h / 50 °C 2.3: pH 5 View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 1 p. 69 - 85
反应条件
1.1: O-(2,4-dinitro-phenyl)-hydroxylamine / acetonitrile / 18 h / 40 °C 1.2: 18 h / 20 °C 2.1: dichloromethane / 18 h / 20 °C 3.1: hydrogen bromide; sodium nitrite / water / 0.25 h / 0 °C 3.2: 0.25 h / 50 °C 3.3: pH 5 View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 1 p. 69 - 85
反应条件
1.1: O-(2,4-dinitro-phenyl)-hydroxylamine / acetonitrile / 18 h / 40 °C 1.2: 18 h / 20 °C 2.1: dichloromethane / 18 h / 20 °C 3.1: hydrogen bromide; sodium nitrite / water / 0.25 h / 0 °C 3.2: 0.25 h / 50 °C 3.3: pH 5 View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 1 p. 69 - 85
反应条件
1: With water; potassium hydroxide in ethanol 3 h; Reflux; 2: With hydrogenchloride in ethanol; water T=20°C; pH=6;
参考文献
IRM LLC; MOLTENI, Valentina; FAN, Yi; LOREN, Jon; SMITH, Jeffrey M.; FLATT, Brenton T.
Patent: WO2012/116217 A1, 2012 ;
Location in patent: Page/Page column 98 ;
WO 2012/116217 A1
