1: 2-chloro-4-methyl-pyridine With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-70°C; 1 h; 2: carbonic acid dimethyl ester in tetrahydrofuran; n-heptane; ethylbenzene T=-40 - 0°C; 1.5 h; 3: With ammonium chloride in tetrahydrofuran; n-heptane; ethylbenzene; water

1: 2-chloro-4-methyl-pyridine With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 1.83333 h; Inert atmosphere; 2: methyl chloroformate in tetrahydrofuran; hexane T=-78 - 0°C; 1.83333 h;