3-氨基-5-氟苯甲酸甲酯合成路线 （共 7 条）
反应条件
thionyl chloride T=0°C; 12 h; Reflux;
参考文献
Chen, Li; Feng, Lichun; Huang, Mengwei; Liu, Yongfu; Wu, Guolong; Wu, Jim Zhen; Zhou, Mingwei
Patent: US2011/257151 A1, 2011 ;
Location in patent: Page/Page column 83; 84 ;
反应条件
5 palladium on charcoal; hydrogen in methanol; water 6 h; Inert atmosphere;
参考文献
BEIGENE, LTD.; ZHOU, Changyou; REN, Bo; WANG, Hexiang
Patent: WO2013/97226 A1, 2013 ;
Location in patent: Page/Page column 46; 47 ;
反应条件
ammonium chloride in ethanol
参考文献
US2013/190249 A1, ;
Page/Page column ;
反应条件
1: thionyl chloride / methanol 2: ammonium chloride / ethanol View Scheme
反应条件
1: sulfuric acid; nitric acid / 2.5 h / 5 - 10 °C / |Inert atmosphere 2: thionyl chloride / 1 h / 10 - 65 °C / |Inert atmosphere 3: acetic acid; iron / ethanol / 1 h / 85 °C / |Inert atmosphere 4: 5 palladium on charcoal; hydrogen / methanol; water / 6 h / |Inert atmosphere View Scheme
反应条件
1: thionyl chloride / 1 h / 10 - 65 °C / |Inert atmosphere 2: acetic acid; iron / ethanol / 1 h / 85 °C / |Inert atmosphere 3: 5 palladium on charcoal; hydrogen / methanol; water / 6 h / |Inert atmosphere View Scheme
反应条件
1: acetic acid; iron / ethanol / 1 h / 85 °C / |Inert atmosphere 2: 5 palladium on charcoal; hydrogen / methanol; water / 6 h / |Inert atmosphere View Scheme
