3-氨基-2-溴-5-氟吡啶合成路线 （共 5 条）
反应条件
hydrogenchloride; tin(ll) chloride in ethanol T=60°C; 1 h;
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James John; MATHIEU, Simon; RUDOLPH, Joachim; LEE, Wendy
Patent: WO2013/92940 A1, 2013 ;
Location in patent: Page/Page column 50; 51 ;
反应条件
1: triethylamine / (BINAP)PdCl2 / 6 h / 100 °C / 3102.97 Torr / Inert atmosphere; Sealed tube 2: N-bromosuccinmide / acetonitrile / 2 h / 20 °C View Scheme
参考文献
NOVARTIS AG; BURGER, Matthew; DRUMM III, Joseph; NISHIGUCHI, Gisele; RICO, Alice; SIMMONS, Robert Lowell; TAFT, Benjamin; TANNER, Huw
Patent: WO2013/175388 A1, 2013 ;
反应条件
triethylamine; (BINAP)PdCl2 T=100°C; P=3102.97 Torr; 6 h; Inert atmosphereSealed tube;
参考文献
NOVARTIS AG; BURGER, Matthew; DING, Yu; HAN, Wooseok; LINDVALL, Mika; NISHIGUCHI, Gisele A.; RICO, Alice; SMITH, Aaron; TANNER, Huw; WAN, Lifeng
Patent: WO2012/4217 A1, 2012 ;
Location in patent: Page/Page column 64 ;
WO 2012/004217 A1
反应条件
1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 h / 0 - 20 °C / |Inert atmosphere 2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James John; MATHIEU, Simon; RUDOLPH, Joachim; LEE, Wendy
Patent: WO2013/92940 A1, 2013 ;
反应条件
triethylamine; Pd0(tris(tert-butyl)phosphine)2
T=145 - 150°C; 5 h;
参考文献
TOYAMA CHEMICAL CO., LTD.; Taisho Pharmaceutical Co. Ltd.
Patent: EP2022793 A1, 2009 ;
Location in patent: Page/Page column 32 ;
Title/Abstract Full Text Show Details
Taisho Pharmaceutical Co. Ltd.; TOYAMA CHEMICAL CO., LTD.
Patent: EP2022793 A1, 2009 ;
Location in patent: Page/Page column 32 ;
EP 2022793 A1
