2,2-二(1H-吲哚-3-基)乙基乙酸酯合成路线 （共 15 条）
反应条件
anhydrous magnesium perchlorate in diethyl ether
T=20°C; 1 h;
参考文献
Bartoli, Giuseppe; Bosco, Marcella; Foglia, Gioia; Giuliani, Arianna; Marcantoni, Enrico; Sambri, Letizia
Synthesis, 2004 , # 6 p. 895 - 900
反应条件
4-(N,N-dimethlyamino)pyridine; benzotriazol-1-ol; dicyclohexyl-carbodiimide in dichloromethane
T=20°C; 16 h; Inert atmosphere;
参考文献
Abe, Takumi; Nakamura, Shuuhei; Yanada, Reiko; Choshi, Tominari; Hibino, Satoshi; Ishikura, Minoru
Organic Letters, 2013 , vol. 15, # 14 p. 3622 - 3625
反应条件
1: 95 percent / H2; AcOH / Pd(OH)2/C / methanol / 18 h
2: 83 percent / NaOAc / ethyl acetate; ethanol
View Scheme
参考文献
Chalaye-Mauger, Helene; Denis, Jean-Noel; Averbuch-Pouchot, Marie-Therese; Vallee, Yannick
Tetrahedron, 2000 , vol. 56, # 5 p. 791 - 804
反应条件
1: 91 percent / ClSiMe3 / CH2Cl2 / 15.5 h / 20 °C
2: 95 percent / H2; AcOH / Pd(OH)2/C / methanol / 18 h
3: 83 percent / NaOAc / ethyl acetate; ethanol
View Scheme
参考文献
Chalaye-Mauger, Helene; Denis, Jean-Noel; Averbuch-Pouchot, Marie-Therese; Vallee, Yannick
Tetrahedron, 2000 , vol. 56, # 5 p. 791 - 804
反应条件
1: indole; glycolaldehyde dimethyl acetal T=20°C; 1.5 h;
2: acetic anhydride With sodium acetate
T=20°C; 17 h;
参考文献
Chakrabarty, Manas; Mukherji, Ajanta
Journal of the Indian Chemical Society, 2013 , vol. 90, # 10 p. 1681 - 1694
反应条件
di-tert-butyl peroxide; iron(II) chloride
T=80°C; 1 h; Inert atmosphere;
参考文献
Guo, Xingwei; Pan, Shiguang; Liu, Jinhua; Li, Zhiping
Journal of Organic Chemistry, 2009 , vol. 74, # 22 p. 8848 - 8851
反应条件
1.1: sulfuric acid / 16 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere
2.2: 1 h / 0 °C
3.1: tri-n-butyl-tin hydride; 2,2'-azo-bisisobutyronitrile / toluene / 16 h / 130 °C / |Inert atmosphere
4.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 16 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Abe, Takumi; Nakamura, Shuuhei; Yanada, Reiko; Choshi, Tominari; Hibino, Satoshi; Ishikura, Minoru
Organic Letters, 2013 , vol. 15, # 14 p. 3622 - 3625
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere
1.2: 1 h / 0 °C
2.1: tri-n-butyl-tin hydride; 2,2'-azo-bisisobutyronitrile / toluene / 16 h / 130 °C / |Inert atmosphere
3.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 16 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Abe, Takumi; Nakamura, Shuuhei; Yanada, Reiko; Choshi, Tominari; Hibino, Satoshi; Ishikura, Minoru
Organic Letters, 2013 , vol. 15, # 14 p. 3622 - 3625
反应条件
1: tri-n-butyl-tin hydride; 2,2'-azo-bisisobutyronitrile / toluene / 16 h / 130 °C / |Inert atmosphere
2: benzotriazol-1-ol; dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 16 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Abe, Takumi; Nakamura, Shuuhei; Yanada, Reiko; Choshi, Tominari; Hibino, Satoshi; Ishikura, Minoru
Organic Letters, 2013 , vol. 15, # 14 p. 3622 - 3625
反应条件
1.1: tetrahydrofuran / 2.5 h / -40 - 0 °C / |Inert atmosphere
1.2: 4 h / 0 °C / |Inert atmosphere
2.1: sulfuric acid / 16 h / 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere
3.2: 1 h / 0 °C
4.1: tri-n-butyl-tin hydride; 2,2'-azo-bisisobutyronitrile / toluene / 16 h / 130 °C / |Inert atmosphere
5.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 16 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Abe, Takumi; Nakamura, Shuuhei; Yanada, Reiko; Choshi, Tominari; Hibino, Satoshi; Ishikura, Minoru
Organic Letters, 2013 , vol. 15, # 14 p. 3622 - 3625
