乙基-4-(2-邻苯二甲酰亚胺基乙氧基)乙酰乙酸乙酯合成路线 (共 4 条)
反应条件
1: N-(2-hydroxyethyl)-phthalimide With sodium hydride in tetrahydrofuran T=-10°C; 0.583333 h; 2: ethyl alpha-chloroacetoacetate in tetrahydrofuran T=-10 - 20°C; 18 h;
参考文献
EOS ECZACIBASI OZGUN KIMYASAL URUNLER SANAYI VE TICARET A.S.
Patent: WO2004/58711 A1, 2004 ;
Location in patent: Page 18, 19 ;
反应条件
1: 25 percent / propan-2-ol / 21 h / Heating 2: methylamine / ethanol / 3 h / Ambient temperature View Scheme
参考文献
Arrowsmith; Campbell; Cross; Stubbs; Burges; Gardiner; Blackburn
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1696 - 1702
反应条件
in propan-1-ol 21 h; Heating / reflux;
参考文献
MATRIX LABORATORIES LTD
Patent: WO2006/3672 A1, 2006 ;
Location in patent: Page/Page column 6; 7 ;
反应条件
in isopropyl alcohol 21 h; Heating;
参考文献
Arrowsmith; Campbell; Cross; Stubbs; Burges; Gardiner; Blackburn
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1696 - 1702