乙基(2-叠氮基乙氧基)乙酰乙酸酯合成路线 (共 5 条)
反应条件
1: 1-azidoethanol With sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide; oil T=20°C; 1 h; 2: ethyl alpha-chloroacetoacetate in tetrahydrofuran; oil T=0 - 20°C; 16.5 h;
参考文献
SYNTA PHAMACEUTICALS CORP.
Patent: WO2005/25507 A2, 2005 ;
Location in patent: Page/Page column 138-139 ;
反应条件
1: NH4OAc / ethanol / 1 h / Heating 2: ethanol / 5 h / Heating 3: 16 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702
参考文献
US4572909 A1, ;
US 4572909 A
反应条件
1: NH4OAc / ethanol / 1 h / Heating 2: ethanol / 5 h / Heating 3: 16 h 4: H2 / 5percent Pd/CaCO3 / ethanol / 1 h / Ambient temperature View Scheme
参考文献
Arrowsmith; Campbell; Cross; Stubbs; Burges; Gardiner; Blackburn
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1696 - 1702