6-溴喹唑啉-2,4-二酮合成路线 （共 12 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in DMF (N,N-dimethyl-formamide) T=100°C; 48 h;
参考文献
WO2004/99159 A1, ;
Page 34; 58; 68 ;
WO 2004/099159 A1
反应条件
T=200°C; 2 h; Inert atmosphere;
参考文献
WO2012/87938 A1, ;
Page/Page column 113-114 ;
WO 2012/087938 A1
反应条件
acetic acid in polyethyleneglycol (PEG-400) T=20 - 60°C; 0.166667 h;
参考文献
Chinese Chemical Letters, , vol. 23, # 4 p. 431 - 433
参考文献
Synlett, , vol. 24, # 16 art. no. ST-2013-B0671-L, p. 2102 - 2106
反应条件
potassium cyanate; acetic acid T=50 - 60°C; 0.833333 h;
参考文献
Heterocycles, , vol. 85, # 11 p. 2745 - 2748,4
Heterocycles, , vol. 85, # 11 p. 2745 - 2748
反应条件
zinc(II) chloride T=200°C; 5 h; sealed tube;
参考文献
Organic Letters, , vol. 11, # 6 p. 1193 - 1196
反应条件
sulfuric acid in dimethyl sulfoxide T=20°C;
参考文献
Chemistry of Heterocyclic Compounds, , vol. 42, # 4 p. 540 - 545
反应条件
1: 30 percent / conc. HCl / o-xylene / 6 h / Heating 2: conc. H2SO4 / dimethylsulfoxide / 20 °C View Scheme
参考文献
Chemistry of Heterocyclic Compounds, , vol. 42, # 4 p. 540 - 545
反应条件
1: 95.2 percent / POCl3, N,N-dimethylaniline / Heating 2: 74 percent / NH3(g) / dimethylformamide / 0.67 h / 35 - 40 °C View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 7 p. 802 - 807
反应条件
N,N-dimethyl-aniline; trichlorophosphate Heating;
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
