2,4,6-三甲基苯胺合成路线 （共 254 条）
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene With [Pd(1,3-bis(2,6-bis(diphenylmethyl)-4-methylphenyl)imidazol-2-ylidene)(cinnamyl)Cl]; potassium 2-methyl-2-butoxide in neat (no solvent)
T=25°C; Buchwald-Hartwig Coupling; 0.0833333 h;
2: 2,4,6-trimethylbenzenamine in neat (no solvent)
T=25°C; Buchwald-Hartwig Coupling; 0.05 h;
参考文献
Chartoire, Anthony; Boreux, Arnaud; Martin, Anthony R.; Nolan, Steven P.
RSC Advances, 2013 , vol. 3, # 12 p. 3840 - 3843
反应条件
1: 2,4,6-trimethylchlorobenzene With [Pd(1,3-bis(2,6-bis(diphenylmethyl)-4-methylphenyl)imidazol-2-ylidene)(cinnamyl)Cl]; potassium 2-methyl-2-butoxide in neat (no solvent)
T=25°C; Buchwald-Hartwig Coupling; 0.0833333 h;
2: 2,4,6-trimethylbenzenamine in neat (no solvent)
T=25°C; Buchwald-Hartwig Coupling; 0.166667 h;
参考文献
Chartoire, Anthony; Boreux, Arnaud; Martin, Anthony R.; Nolan, Steven P.
RSC Advances, 2013 , vol. 3, # 12 p. 3840 - 3843
反应条件
C23H38IrN3O(2+)*2BF4(1-) in toluene; acetonitrile
T=110°C; 12 h; Inert atmosphere;
参考文献
Bartoszewicz, Agnieszka; Marcos, Rocio; Sahoo, Suman; Inge, A. Ken; Zou, Xiaodong; Martin-Matute, Belen
Chemistry - A European Journal, 2012 , vol. 18, # 45 p. 14510 - 14519
反应条件
tetrabutyl-ammonium chloride
T=45°C; 2 h; Ionic liquid;
参考文献
Monopoli, Antonio; Cotugno, Pietro; Cortese, Marina; Calvano, Cosima Damiana; Ciminale, Francesco; Nacci, Angelo
European Journal of Organic Chemistry, 2012 , # 16 p. 3105 - 3111
反应条件
di-tert-butyl peroxide; C6H6*2C17H13Cl4CuN2
T=90°C; 24 h; Inert atmosphereNeat (no solvent);
参考文献
Gephart III, Raymond T.; Huang, Daria L.; Aguila, Mae Joanne B.; Schmidt, Graham; Shahu, Andi; Warren, Timothy H.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 26 p. 6488 - 6492
反应条件
triethylamine in dichloromethane
参考文献
Lortie, Frederic; Boileau, Sylvie; Bouteiller, Laurent
Chemistry - A European Journal, 2003 , vol. 9, # 13 p. 3008 - 3014
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile
T=82°C; 18 h;
参考文献
Knoelker, Hans-Joachim; Braxmeier, Tobias; Schlechtingen, Georg
Angewandte Chemie, 1995 , vol. 107, # 22 p. 2746 - 2749
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile
T=25°C; 4 h;
参考文献
Knoelker, Hans-Joachim; Braxmeier, Tobias; Schlechtingen, Georg
Angewandte Chemie, 1995 , vol. 107, # 22 p. 2746 - 2749
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile
T=82°C; 360 h;
参考文献
Knoelker, Hans-Joachim; Braxmeier, Tobias; Schlechtingen, Georg
Angewandte Chemie, 1995 , vol. 107, # 22 p. 2746 - 2749
参考文献
Baugh, Lisa S.; Berluche, Enock; Hinkle, Paul V.; Rix, Francis C.
Patent: US2006/173144 A1, 2006 ;
