potassium carbonate in N,N-dimethyl-formamide 24 h; under vacuum;

1: 1.) POCl3 / 1.) RT, 2 h; 2.) chlorobenzene, 60 deg C, 3 h 2: 95 percent / 98percent formic acid, 30percent hydrogen peroxide / CH2Cl2 / 2.5 h 3: 89 percent / K2CO3 / acetone / 6 h / Heating 4: 73 percent / H2 / Pd/C / diethyl ether; methanol 5: 6.8 g / HCl gas / diethyl ether 6: 84 percent / K2CO3 / dimethylformamide / 24 h / under vacuum View Scheme

1: 95 percent / 98percent formic acid, 30percent hydrogen peroxide / CH2Cl2 / 2.5 h 2: 89 percent / K2CO3 / acetone / 6 h / Heating 3: 73 percent / H2 / Pd/C / diethyl ether; methanol 4: 6.8 g / HCl gas / diethyl ether 5: 84 percent / K2CO3 / dimethylformamide / 24 h / under vacuum View Scheme

1: 89 percent / K2CO3 / acetone / 6 h / Heating 2: 73 percent / H2 / Pd/C / diethyl ether; methanol 3: 6.8 g / HCl gas / diethyl ether 4: 84 percent / K2CO3 / dimethylformamide / 24 h / under vacuum View Scheme

1: 73 percent / H2 / Pd/C / diethyl ether; methanol 2: 6.8 g / HCl gas / diethyl ether 3: 84 percent / K2CO3 / dimethylformamide / 24 h / under vacuum View Scheme

1: 6.8 g / HCl gas / diethyl ether 2: 84 percent / K2CO3 / dimethylformamide / 24 h / under vacuum View Scheme