7-甲氧基-2,3-二氢喹啉-4-酮合成路线 （共 14 条）
反应条件
palladium 10 on activated carbon; sodium hydroxide in water; isopropyl alcohol 16 h; Inert atmosphereReflux;
参考文献
Lange, Jens; Bissember, Alex C.; Banwell, Martin G.; Cade, Ian A.
Australian Journal of Chemistry, 2011 , vol. 64, # 4 p. 454 - 470
反应条件
N2; NaHSO4 in tetrahydrofuran
参考文献
Ligand Pharmaceuticals Incorporated
Patent: US5688808 A1, 1997 ;
US 5688808 A
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran Ambient temperature;
参考文献
Edwards, James P.; Higuchi, Robert I.; Winn, David T.; Pooley, Charlotte L. F.; Caferro, Thomas R.; Hamann, Lawrence G.; Zhi, Lin; Marschke, Keith B.; Goldman, Mark E.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 7 p. 1003 - 1008
反应条件
1: DMAP / tetrahydrofuran / Ambient temperature 2: 1.) LiAlH4, 2.) H2, AcOH / 2) Pd/C / 1.) from 0 deg C to RT, 2.) EtOAC, EtOH 3: BBr3 / CH2Cl2 / -78 - 0 °C View Scheme
参考文献
Edwards, James P.; Higuchi, Robert I.; Winn, David T.; Pooley, Charlotte L. F.; Caferro, Thomas R.; Hamann, Lawrence G.; Zhi, Lin; Marschke, Keith B.; Goldman, Mark E.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 7 p. 1003 - 1008
参考文献
Kasiotis, Konstantinos M.; Fokialakis, Nikolas; Haroutounian, Serkos A.
Synthesis, 2006 , # 11 p. 1791 - 1802
反应条件
trifluorormethanesulfonic acid in dichloromethane
T=0 - 18°C; Fries rearrangement; 1 h; Inert atmosphere;
参考文献
Lange, Jens; Bissember, Alex C.; Banwell, Martin G.; Cade, Ian A.
Australian Journal of Chemistry, 2011 , vol. 64, # 4 p. 454 - 470
反应条件
1: 85 percent / toluene / Heating
2: 77 percent / PPA / 90 °C
View Scheme
参考文献
Kasiotis, Konstantinos M.; Fokialakis, Nikolas; Haroutounian, Serkos A.
Synthesis, 2006 , # 11 p. 1791 - 1802
反应条件
1: aq. NaOH / ethanol / Heating
2: 85percent polyphosphoric acid / 1.) r.t., 0.5 h; 60 deg C, overnight, 2.) 70-80 deg C, 2 h; 100 deg C, 1 h
View Scheme
参考文献
Booker-Milburn, Kevin I.; Dunkin, Ian R.; Kelly, Frances C.; Khalaf, Abedawn I.; Learmonth, David A.; Proctor, George R.; Scopes, David I. C.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 21 p. 3261 - 3273
反应条件
1: copper(l) iodide; potassium carbonate / toluene / 20 h / 18 - 140 °C / Inert atmosphere; Sealed
2: trifluorormethanesulfonic acid / dichloromethane / 1 h / 0 - 18 °C / Inert atmosphere
View Scheme
参考文献
Lange, Jens; Bissember, Alex C.; Banwell, Martin G.; Cade, Ian A.
Australian Journal of Chemistry, 2011 , vol. 64, # 4 p. 454 - 470
反应条件
1: 45 percent / ethylmagnesium bromide / tetrahydrofuran / 14 h
2: 40 percent / trifluoroacetic acid / Heating
View Scheme
参考文献
Kano, Shinzo; Ebata, Tsutomu; Shibuya, Shiroshi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2105 - 2111
