2-氰基-3-羟基-2-丁烯酸乙酯合成路线 （共 6 条）
反应条件
phosphorus pentachloride in benzene 3 h; Heating;
参考文献
Kasum, Bruno; Prager, Rolf H.
Australian Journal of Chemistry, 1983 , vol. 36, # 7 p. 1455 - 1467
反应条件
1: 62 percent / PCl5 / benzene / 3 h / Heating 2: 80 percent / dimethylformamide / 3 h / 80 °C View Scheme
参考文献
Kasum, Bruno; Prager, Rolf H.
Australian Journal of Chemistry, 1983 , vol. 36, # 7 p. 1455 - 1467
反应条件
1: cyanoacetic acid ethyl ester With potassium carbonate in N,N-dimethyl-formamide
T=20°C; 0.25 h;
2: acetic anhydride in N,N-dimethyl-formamide
T=20°C;
参考文献
ALEMBIC LIMITED
Patent: WO2009/147624 A2, 2009 ;
Location in patent: Page/Page column 6 ;
反应条件
1: With potassium carbonate in tetrahydrofuran; water
T=20°C; 1 h;
2: With hydrogenchloride in tetrahydrofuran; water
T=0°C; pH=Ca. 2; Further stages;
参考文献
Akula, Ramulu; Xiong, Yan; Ibrahim, Hasim
RSC Advances, 2013 , vol. 3, # 27 p. 10731 - 10735
反应条件
1.1: NaH in oil / tetrahydrofuran / 20 °C
1.2: 78 percent / tetrahydrofuran / 4.5 h / 20 °C
2.1: 73 percent / aq. HCl
View Scheme
参考文献
Maezaki, Naoyoshi; Furusawa, Akemi; Uchida, Shuji; Tanaka, Tetsuaki
Heterocycles, 2003 , vol. 59, # 1 p. 161 - 167
反应条件
1: 62 percent / PCl5 / benzene / 3 h / Heating
2: 63 percent / dimethylformamide / 24 h / 140 °C
View Scheme
参考文献
Kasum, Bruno; Prager, Rolf H.
Australian Journal of Chemistry, 1983 , vol. 36, # 7 p. 1455 - 1467
