1: 80 percent / O2, PdCl2, CuCl / dimethylformamide; H2O 2: 1.) LDA, 2.) HMPA / 1.) THF, -78 deg C, 1 h, 2.) overnight View Scheme

1: 100 percent / p-TsOH / benzene / Heating 2: 80 percent / O2, PdCl2, CuCl / dimethylformamide; H2O 3: 1.) LDA, 2.) HMPA / 1.) THF, -78 deg C, 1 h, 2.) overnight View Scheme

1: 91 percent / Et3N / CH2Cl2 / 0.5 h / 0 °C 2: 1.) LDA, 2.) HMPA / 1.) THF, -78 deg C, 1 h, 2.) overnight View Scheme

N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide 1.) THF, -78 deg C, 1 h, 2.) overnight; Yield given. Multistep reaction;