5-氯吲哚-2-羧酸甲酯合成路线 （共 14 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine in tetrahydrofuran T=110°C; P=7600.51 Torr; 20 h; Autoclave;
参考文献
Vieira, Tiago O.; Meaney, Laura A.; Shi, Yong-Ling; Alper, Howard
Organic Letters, 2008 , vol. 10, # 21 p. 4899 - 4901
反应条件
1: 81 percent / sodium methoxide / methanol / 4 h / -10 °C 2: 84 percent / Rh2(pbf)4 / toluene / 16 h / 60 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 24 p. 7500 - 7501
反应条件
aluminium trichloride in dichloromethane T=20°C; intramolecular Friedel-Crafts heteroannulation; 24 h;
参考文献
Cruz, Maria Del Carmen; Jimenez, Fabiola; Delgado, Francisco; Tamariz, Joaquin
Synlett, 2006 , # 5 p. 749 - 755
反应条件
copper(I) oxide; caesium carbonate in 1-methyl-pyrrolidin-2-one T=100°C; 16 h; Inert atmosphereSealed tube;
参考文献
Zhu, Zhiqiang; Yuan, Jiangjun; Zhou, Yirong; Qin, Yang; Xu, Jingshi; Peng, Yiyuan
European Journal of Organic Chemistry, 2014 , vol. 2014, # 3 p. 511 - 514
反应条件
sulfuric acid in methanol
参考文献
US6403561 B1, ;
US 6403561 B1
反应条件
thionyl chloride T=0°C;
参考文献
Bashiardes, George; Safir, Imad; Barbot, Francis
Synlett, 2007 , # 11 p. 1707 - 1710
反应条件
in anhydrous xylene T=140°C; 2 h;
参考文献
Ranasinghe, Nadeesha; Jones, Graham B.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1740 - 1742
反应条件
1: With tetrabutyl-ammonium chloride; sodium formate; sodium hydrogencarbonate; palladium diacetate; sodium chloride Heck coupling; 1 h; 2: With acetic anhydride 12 h; Heating;
参考文献
Tullberg, Erik; Schacher, Felix; Peters, Dan; Frejd, Torbjoern
Synthesis, 2006 , # 7 p. 1183 - 1189
反应条件
1: K2CO3 / acetone / 12 h / 60 °C 2: 72 percent / 5 h / 90 °C 3: 61 percent / AlCl3 / CH2Cl2 / 24 h / 20 °C View Scheme
参考文献
Synlett, , # 5 p. 749 - 755
反应条件
1: 72 percent / 5 h / 90 °C 2: 61 percent / AlCl3 / CH2Cl2 / 24 h / 20 °C View Scheme
参考文献
Synlett, , # 5 p. 749 - 755
