甲基1,3-苯并噻唑-2-羧酸酯合成路线 （共 17 条）
反应条件
1: cyclobenzothiazole; carbon dioxide With caesium carbonate in N,N-dimethyl-formamide
T=125°C; P=1064.07 Torr; 16 h;
2: methyl iodide in N,N-dimethyl-formamide
Heating;
参考文献
Vechorkin, Oleg; Hirt, Nathalie; Hu, Xile
Organic Letters, 2010 , vol. 12, # 15 p. 3567 - 3569
反应条件
ytterbium(III) triflate in toluene
1.5 h; Heating / reflux;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2004/22060 A2, 2004 ;
Location in patent: Page/Page column 43 ;
WO 2004/022060 A2
反应条件
sodium peroxodisulphate; sulfuric acid; silver nitrate in dichloromethane
1.5 h; Heating;
参考文献
Coppa, Fausta; Fontana, Francesca; Lazzarini, Edoardo; Minisci, Francesco; Pianese, Guiseppe; Zhao, Lihua
Tetrahedron Letters, 1992 , vol. 33, # 21 p. 3057 - 3060
反应条件
[bis(acetoxy)iodo]benzene
T=10°C; 6 h;
参考文献
Prakash, Om; Sharma, Vijay; Sadana, Anil
Journal of Chemical Research - Part S, 1996 , # 2 p. 100 - 101
反应条件
1: C27H37ClCuN3; potassium tert-butylate / tetrahydrofuran / 8 h / 80 °C / 760.05 Torr / Inert atmosphere; sealed tube
2: N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; sealed tube
View Scheme
参考文献
Inomata, Hiroshi; Ogata, Kenichi; Fukuzawa, Shin-Ichi; Hou, Zhaomin
Organic Letters, 2012 , vol. 14, # 15 p. 3986 - 3989
反应条件
in benzene
T=18 - 20°C; 1.5 h; regioselective reaction;
参考文献
Makarenko; Kovalenko; Vershinina, Ya. S.; Berestovitskaya
Russian Journal of Organic Chemistry, 2014 , vol. 50, # 1 p. 83 - 86
Zh. Org. Khim., 2014 , vol. 50, # 1 p. 89 - 92,4
反应条件
in N,N-dimethyl-formamide
T=80°C; 1 h; Inert atmospheresealed tube;
参考文献
Inomata, Hiroshi; Ogata, Kenichi; Fukuzawa, Shin-Ichi; Hou, Zhaomin
Organic Letters, 2012 , vol. 14, # 15 p. 3986 - 3989
反应条件
in benzene
T=18 - 20°C; 1.5 h; regioselective reaction;
参考文献
Makarenko; Kovalenko; Vershinina, Ya. S.; Berestovitskaya
Russian Journal of Organic Chemistry, 2014 , vol. 50, # 1 p. 83 - 86
Zh. Org. Khim., 2014 , vol. 50, # 1 p. 89 - 92,4
反应条件
hydrogenchloride
T=50°C; overnight;
参考文献
Liso, Gaetano; Trapani, Giuseppe; Latrofa, Andrea
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1683 - 1684
参考文献
Liso, Gaetano; Trapani, Giuseppe; Latrofa, Andrea
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1683 - 1684
