1-(3-(2-(7-氯-2-喹啉)乙烯)苯基)乙酮合成路线 (共 3 条)
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane
T=-60 - -50°C; 0.5 h;
2: 3-(7-Chloroquinol-2-yl-trans-ethenyl)-alpha-methylbenzyl alcohol in dichloromethane
T=-60 - -50°C; 0.75 h;
3: With triethylamine in dichloromethane
T=-60 - 10°C; 1.16667 h;
参考文献
MOREPEN LABORATORIES LIMITED
Patent: WO2006/21974 A1, 2006 ;
Location in patent: Page/Page column 21-22 ;
反应条件
MeMgBr in tetrahydrofuran
参考文献
Merck Frosst Canada, Inc.
Patent: US5270324 A1, 1993 ;
反应条件
1: 1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)ethanone With sodium methylate in 1,4-dioxane
T=20 - 30°C; 0.25 - 0.333333 h;
2: carbonic acid dimethyl ester in 1,4-dioxane
T=75 - 80°C; 8 - 10 h;
参考文献
MOREPEN LABORATORIES LIMITED
Patent: WO2006/21974 A1, 2006 ;
Location in patent: Page/Page column 22 ;