hydrogenchloride; water; acetic acid T=120°C; 6 h; Product distribution / selectivity;

1.1: AlCl3, aluminium chloride / chloroform / 0.5 h / 0 °C / |Inert atmosphere 1.2: 4 h / 0 - 20 °C / |Inert atmosphere 2.1: sodium hydroxide; water / toluene / 1.5 h / 50 - 60 °C / |Inert atmosphere 3.1: hydrazine hydrate; potassium hydroxide / 16 h / -50 - 100 °C / |Inert atmosphere View Scheme

1: sodium hydroxide; water / toluene / 1.5 h / 50 - 60 °C / |Inert atmosphere 2: hydrazine hydrate; potassium hydroxide / 16 h / -50 - 100 °C / |Inert atmosphere View Scheme

1.1: sodium hydroxide / toluene / 3 h / 50 - 60 °C 1.2: 1 h / 0 - 23 °C 2.1: hydrazine hydrate / toluene / -50 - 23 °C 2.2: 80 °C / |Reflux View Scheme

sulfuric acid in methanol; water Heating / reflux;

sulfuric acid 1.5 h; Heating / reflux;

1.1: potassium carbonate; pivaloyl chloride / acetone / 0.33 h / -10 - 20 °C / |Inert atmosphere 2.1: lithium hexamethyldisilazane; n-butyllithium / hexane; tetrahydrofuran / 1 h / -45 - 0 °C / |Inert atmosphere 2.2: 3 h / -45 - 0 °C / |Inert atmosphere 3.1: pyridinium p-toluenesulfonate / ethanol / 2 h / 50 °C / |Inert atmosphere 4.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / dichloromethane / 0.33 h / 25 °C / |Molecular sieve; |Inert atmosphere 5.1: hydrogenchloride / water; 1,4-dioxane / 18 h / 120 °C / |Inert atmosphere 6.1: formic acid; dihydrogen peroxide / water / 1 h / 0 °C / |Inert atmosphere 7.1: potassium permanganate / water; methanol / 1 h / 25 °C / |Inert atmosphere View Scheme

1.1: potassium carbonate; pivaloyl chloride / acetone / 0.33 h / -10 - 20 °C / |Inert atmosphere 2.1: lithium hexamethyldisilazane; n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -15 - -7 °C / |Inert atmosphere 2.2: 3 h / -15 - 0 °C / |Inert atmosphere 3.1: sulfuric acid / water; 1,4-dioxane / 18 h / |Inert atmosphere; |Reflux 4.1: 3,3-dimethyldioxirane / acetone / 1 h / 25 °C / |Inert atmosphere 5.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane; toluene / 1 h / 25 °C / |Inert atmosphere 5.2: 18 h / -10 - 25 °C / |Inert atmosphere View Scheme