反应条件
1.1: 4-methyl-morpholine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / -15 °C / Inert atmosphere
2.2: -15 - 25 °C / Inert atmosphere
3.1: dimethylphenylsilane; trifluoroacetic acid / 5 h / 0 °C / Inert atmosphere
View Scheme
参考文献
Smith, Cameron J.; Ali, Amjad; Hammond, Milton L.; Li, Hong; Lu, Zhijian; Napolitano, Joann; Taylor, Gayle E.; Thompson, Christopher F.; Anderson, Matt S.; Chen, Ying; Eveland, Suzanne S.; Guo, Qiu; Hyland, Sheryl A.; Milot, Denise P.; Sparrow, Carl P.; Wright, Samuel D.; Cumiskey, Anne-Marie; Latham, Melanie; Peterson, Laurence B.; Rosa, Ray; Pivnichny, James V.; Tong, Xinchun; Xu, Suoyu S.; Sinclair, Peter J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4880 - 4895