1-[1-(1H-咪唑-1-甲基)环丙基]甲胺合成路线 （共 4 条）
反应条件
hydrogenchloride in 1,4-dioxane
T=0°C; 1 h;
参考文献
Buchholz, Mirko; Heiser, Ulrich; Schilling, Stephan; Niestroj, Andre J.; Zunkel, Katrin; Demuth, Hans-Ulrich
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 664 - 677
反应条件
1.1: Et3N / CH2Cl2 / 15 h / 0 - 20 °C
2.1: NaH / dimethylformamide
2.2: 43.5 percent / dimethylformamide / 8 h / 100 °C
3.1: HCl / dioxane / 1 h / 0 °C
View Scheme
参考文献
Buchholz, Mirko; Heiser, Ulrich; Schilling, Stephan; Niestroj, Andre J.; Zunkel, Katrin; Demuth, Hans-Ulrich
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 664 - 677
反应条件
1.1: 79.6 percent / LiAlH4 / tetrahydrofuran / 6 h
2.1: 0.28 g / Et3N / methanol / 12 h / 50 °C
3.1: Et3N / CH2Cl2 / 15 h / 0 - 20 °C
4.1: NaH / dimethylformamide
4.2: 43.5 percent / dimethylformamide / 8 h / 100 °C
5.1: HCl / dioxane / 1 h / 0 °C
View Scheme
参考文献
Buchholz, Mirko; Heiser, Ulrich; Schilling, Stephan; Niestroj, Andre J.; Zunkel, Katrin; Demuth, Hans-Ulrich
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 664 - 677
反应条件
1.1: 0.28 g / Et3N / methanol / 12 h / 50 °C
2.1: Et3N / CH2Cl2 / 15 h / 0 - 20 °C
3.1: NaH / dimethylformamide
3.2: 43.5 percent / dimethylformamide / 8 h / 100 °C
4.1: HCl / dioxane / 1 h / 0 °C
View Scheme
参考文献
Buchholz, Mirko; Heiser, Ulrich; Schilling, Stephan; Niestroj, Andre J.; Zunkel, Katrin; Demuth, Hans-Ulrich
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 664 - 677
