N-(2-苯乙基)乙酰胺合成路线 （共 94 条）
反应条件
1: chlorosulfuric acid 2: aqueous ammonia View Scheme
参考文献
Miller et al.
Journal of the American Chemical Society, 1940 , vol. 62, p. 2099,2101
反应条件
tetrachloromethane; dinitrogen trioxide
参考文献
Murakami; Akagi
Nippon Kagaku Zasshi, 1954 , vol. 75, p. 532,534
Chem.Abstr., 1957 , p. 11242
反应条件
1: 80 percent / PPA / 3 h / 180 °C 2: 81 percent / Ph2S2 / 1,2,3,4-tetrahydro-naphthalene / 20 h / 200 °C View Scheme
参考文献
Spaeth et al.
Chemische Berichte, 1930 , vol. 63, p. 134,136
反应条件
1: 80 percent / PPA / 3 h / 180 °C 2: 81 percent / Ph2S2 / 1,2,3,4-tetrahydro-naphthalene / 20 h / 200 °C 3: 79 percent / conc. HNO3, conc. H2SO4 / 2 h / 60 °C View Scheme
参考文献
Rathelot; Vanelle; Gasquet; Delmas; Crozet; Timon-David; Maldonado
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 6 p. 503 - 508
反应条件
1: N-(2-phenylethyl)-acetamide With triphenyl phosphite; chlorine; triethylamine in dichloromethane T=-30°C; 2 h; 2: methanol in dichloromethane T=-30 - 20°C; 5 h; 3: With water 12 h;
参考文献
Spaggiari, Alberto; Blaszczak, Larry C.; Prati, Fabio
Organic Letters, 2004 , vol. 6, # 22 p. 3885 - 3888
反应条件
aluminium trichloride in dichloromethane T=0 - 20°C; Friedel-Crafts reaction;
参考文献
Day, Robert F.; Lafontaine, Jennifer A.
Patent: US2002/52392 A1, 2002 ;
US 20020052392 A1
反应条件
aluminium trichloride; tetrachloroethane, 1,1,2,2-
参考文献
Blicke; Lilienfeld
Journal of the American Chemical Society, 1943 , vol. 65, p. 2377
反应条件
1: 76 g / conc. H2SO4; conc. HNO3 / 2 h 2: 99 percent / 47percent HBr / 6 h / Heating View Scheme
参考文献
Liu, Hong; Ji, Ming; Luo, Xiaomin; Shen, Jianhua; Huang, Xiaoqin; Hua, Weiyi; Jiang, Hualiang; Chen, Kaixian
Journal of Medicinal Chemistry, 2002 , vol. 45, # 14 p. 2953 - 2969
反应条件
1: 1.) AlCl3, 2.) 6 N aq. HCl, 3.) 10 N NaHCO3, NaOH 2: 75 percent / potassium tert-butoxide / tetrahydrofuran / 1.5 h / -20 - 10 °C View Scheme
参考文献
Soyka; Heckel; Nickl; Eisert; Muller; Weisenberger
Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 26 - 39
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile 20 h; Ambient temperature; Yield given;
参考文献
Grehn, Leif; Gunnarsson, Kerstin; Ragnarsson, Ulf
Journal of the Chemical Society, Chemical Communications, 1985 , # 19 p. 1317 - 1318
