4-(三甲基甲硅烷基)苯甲醚合成路线 （共 34 条）
反应条件
N-chloro-succinimide; sodium bromide in methanol 0.0833333 h; Ambient temperature; Yield given;
参考文献
Journal of Organic Chemistry, , vol. 48, # 9 p. 1542 - 1544
反应条件
sodium; ammonium hydroxide in diethyl ether; ethanol T=-30 - 20°C;
参考文献
SCHERING CORPORATION
Patent: WO2006/98961 A2, 2006 ;
Location in patent: Page/Page column 167; 168 ;
反应条件
dichloro bis(acetonitrile) palladium(II); 1,2-dichloro-ethane; copper dichloride
T=80°C; 16 h; Inert atmosphere; Overall yield = 64 percent; Overall yield = 76 mg; regioselective reaction;
参考文献
Funaki, Kenji; Sato, Tetsuo; Oi, Shuichi
Organic Letters, 2012 , vol. 14, # 24 p. 6186 - 6189
反应条件
1.1: ammonia; sodium / ethanol; diethyl ether / 16 h / -78 - -33 °C
1.2: 2 h / 20 °C
2.1: lithium aluminium tetrahydride / diethyl ether / 4 h / 20 °C
View Scheme
参考文献
BIOGEN IDEC MA INC.; GUCKIAN, Kevin; KUMARAVEL, Gnanasambandam; MA, Bin; MI, Sha; PENG, Hairuo; SHAO, Zhaohui; SUN, Lihong; TAVERAS, Arthur; XIN, Zhili; ZHANG, Lei
Patent: WO2014/18891 A1, 2014 ;
