2 -溴- 4 -氯苯丙酮合成路线 （共 19 条）
反应条件
1: sodium azide / acetonitrile / 3 h / 60 °C 2: triethyl phosphite; hydrogen chloride / toluene / 0 - 20 °C View Scheme
参考文献
Ermert; Hamacher; Coenen
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 14 p. 1345 - 1363
反应条件
diethylamine in DMF (N,N-dimethyl-formamide) T=0 - 40°C; 3.5 h;
参考文献
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; JEIL PHARMACEUTICAL CO., LTD.
Patent: WO2005/92896 A1, 2005 ;
Location in patent: Page/Page column 34; 36 ;
WO 2005/092896 A1
反应条件
ammonium acetate on neutral alumina; silica gel in benzene T=80°C; 6 h;
参考文献
Tetrahedron, , vol. 62, # 14 p. 3201 - 3213
反应条件
7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene on polystyrene.HL in tetrahydrofuran Cyclization; 24 h; Heating;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 17 p. 2425 - 2428
参考文献
Temnikowa; Kulatschkowa
Zhurnal Obshchei Khimii, 1949 , vol. 19, p. 1324,1339
Chem.Abstr., 1950 , p. 4442
反应条件
1: 42 percent / NaH / tetrahydrofuran / 1.5 h / Heating 2: sodium / ethanol / 2.5 h / 0 °C 3: 45 percent / NaOH / ethanol / 1.5 h / Alkaline hydrolysis 4: DMF / CH2Cl2 / 3 h / 20 °C 5: 66 percent / triethylamine / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Dutta, Aloke K.; Sard, Howard; Ryan, William; Razdan, Raj K.; Compton, David R.; Martin, Billy R.
Medicinal Chemistry Research, 1995 , vol. 5, # 1 p. 54 - 62
反应条件
1: 42 percent / NaH / tetrahydrofuran / 1.5 h / Heating 2: sodium / ethanol / 2.5 h / 0 °C 3: 45 percent / NaOH / ethanol / 1.5 h / Alkaline hydrolysis View Scheme
参考文献
Medicinal Chemistry Research, , vol. 5, # 1 p. 54 - 62
反应条件
bromine
T=20°C; 0.333333 h;
参考文献
Lagoja, Irene M.; Pannecouque, Christophe; Van Aerschot, Arthur; Witvrouw, Myriam; Debyser, Zeger; Balzarini, Jan; Herdewijn, Piet; De Clercq, Erik
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1546 - 1553
反应条件
1: chlorobenzene With AlCl3, aluminium chloride in dichloromethane
T=10 - 15°C; 1 h;
2: α-bromopropionyl bromide in dichloromethane
T=20°C; 16 h;
3: With water in dichloromethane
T=0°C;
参考文献
Botton, Gerard; Leriche, Caroline; Arbellot De Vacqueur, Annick; Audet, Annick; Gleitz, Johannes
Patent: US2010/286129 A1, 2010 ;
Location in patent: Page/Page column 21 ;
反应条件
bromine in chloroform
参考文献
Nihon Bayer Agrochem K.K.
Patent: US5389648 A1, 1995 ;
