2-(4-氧代-3-苯基-4H-色烯-8-基)乙酸合成路线 （共 2 条）
反应条件
1: 1.) hexamethylenetetramine; 3.) cc. HCl / 1.) CH3Cl, 2 h, reflux; 2.) AcOH, 2 h, reflux; 3.) RT, overnight
2: 1.) 50 percent NaH / 1.) dioxane, 1 h, RT; 2.) 1 h, 50 deg C
View Scheme
参考文献
Atassi; Briet; Berthelon; Collonges
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 5 p. 393 - 402
反应条件
sodium hydride
1.) dioxane, 1 h, RT; 2.) 1 h, 50 deg C; Yield given. Multistep reaction;
参考文献
Atassi; Briet; Berthelon; Collonges
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 5 p. 393 - 402
