5S-碘-1S,6S-3,7-二氧杂双环[4,3,0]-壬烷-8-酮合成路线 （共 4 条）
反应条件
1: 86 percent / NaBH4 / ethanol 2: 93 percent / imidazole / dimethylformamide 3: 94 percent / xylene / 7 h / Heating 4: 81 percent / tetrahydrofuran / -78 °C 5: 85 percent / N-Methylmorpholine-N-oxide, OsO4 6: 93 percent / anhydr. CuSO4, TsOH 7: 75 percent / tetrahydrofuran / 24 h / Ambient temperature 8: 87 percent / Bu4NF / tetrahydrofuran / 4 h / Ambient temperature 9: 80 percent / PCC,molecular sieve / CH2Cl2 / 1 h / Ambient temperature 10: 1.) n-BuLi / 2.) THF, -40 to -30 deg C, 2 h and 0 deg C, 30 min. 11: 50percent aq. AcOH / 72 h / Ambient temperature View Scheme
参考文献
Fleet, G. W. J.; Gough, M. J.; Shing, T. K. M.
Tetrahedron Letters, 1983 , vol. 24, # 34 p. 3661 - 3664
反应条件
sodium tetrahydroborate in ethanol
参考文献
Fleet, G. W. J.; Gough, M. J.; Shing, T. K. M.
Tetrahedron Letters, 1983 , vol. 24, # 34 p. 3661 - 3664
反应条件
1: 86 percent / NaBH4 / ethanol
2: 93 percent / imidazole / dimethylformamide
View Scheme
参考文献
Fleet, G. W. J.; Gough, M. J.; Shing, T. K. M.
Tetrahedron Letters, 1983 , vol. 24, # 34 p. 3661 - 3664
反应条件
1: 86 percent / NaBH4 / ethanol
2: 93 percent / imidazole / dimethylformamide
3: 94 percent / xylene / 7 h / Heating
4: 81 percent / tetrahydrofuran / -78 °C
5: 85 percent / N-Methylmorpholine-N-oxide, OsO4
6: 93 percent / anhydr. CuSO4, TsOH
7: 75 percent / tetrahydrofuran / 24 h / Ambient temperature
8: 87 percent / Bu4NF / tetrahydrofuran / 4 h / Ambient temperature
9: 80 percent / PCC,molecular sieve / CH2Cl2 / 1 h / Ambient temperature
10: 1.) n-BuLi / 2.) THF, -40 to -30 deg C, 2 h and 0 deg C, 30 min.
11: 50percent aq. AcOH / 72 h / Ambient temperature
View Scheme
参考文献
Fleet, G. W. J.; Gough, M. J.; Shing, T. K. M.
Tetrahedron Letters, 1983 , vol. 24, # 34 p. 3661 - 3664
