5-溴咪唑并[1,2-a]吡嗪-2-羧酸乙酯合成路线 （共 4 条）
反应条件
bromine in ethanol
1 h; Heating;
参考文献
Sablayrolles; Cros; Milhavet; Rechenq; Chapat; Boucard; Serrano; McNeill
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 206 - 212
反应条件
1: 1.) ether, HMPT, reflux, 3 h, 2.) EtOH, reflux, 1 h
2: 67 percent / Br2 / ethanol / 1 h / Heating
View Scheme
参考文献
Sablayrolles; Cros; Milhavet; Rechenq; Chapat; Boucard; Serrano; McNeill
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 206 - 212
反应条件
ammonium hydroxide
1 h; Heating;
参考文献
Sablayrolles; Cros; Milhavet; Rechenq; Chapat; Boucard; Serrano; McNeill
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 206 - 212
反应条件
1: 45 percent / concd. aq. NH4OH / 1 h / Heating
2: 55 percent / POCl3 / 1 h / Heating
View Scheme
参考文献
Sablayrolles; Cros; Milhavet; Rechenq; Chapat; Boucard; Serrano; McNeill
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 206 - 212
