N-[2-[2-[2-(2-叠氮乙氧基)乙氧基]乙氧基]乙基]生物素胺合成路线 （共 5 条）
反应条件
1: 1-amino-11-azido-3,6,9-trioxaundecane With triethylamine in N,N-dimethyl-formamide 0.5 h; 2: D-biotin-N-hydroxysuccinimide ester in N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; KOHN, Harold, L.; PARK, Ki Duk
Patent: WO2010/14236 A2, 2010 ;
Location in patent: Page/Page column 35 ;
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Tantama, Mathew; Lin, Wan-Chen; Licht, Stuart
Journal of the American Chemical Society, 2008 , vol. 130, # 47 p. 15766 - 15767
反应条件
trifluoromethanesulfonyl azide; copper(II) sulfate; triethylamine in methanol; dichloromethane; water T=0 - 25°C;
参考文献
Yun, Wang; Shougang, Hu; Fast, Walter
Journal of the American Chemical Society, 2009 , vol. 131, # 42 p. 15096 - 15097
反应条件
triethylamine in tetrahydrofuran T=20°C; 12 h; Inert atmosphere;
参考文献
Tae, Hyun Seop; Hines, John; Schneekloth, Ashley R.; Crews, Craig M.
Organic Letters, 2010 , vol. 12, # 19 p. 4308 - 4311
反应条件
water; triphenylphosphine in tetrahydrofuran T=20°C; Staudinger reaction; 12 h;
参考文献
Fusz, Stefan; Srivatsan, Seergazhi G.; Ackermann, Damian; Famulok, Michael
Journal of Organic Chemistry, 2008 , vol. 73, # 13 p. 5069 - 5077
