4-(二乙基膦酰)-3-甲基-2-丁烯腈合成路线 （共 3 条）
反应条件
T=180°C; 8 h; Inert atmosphere;
参考文献
Sovdat, Tina; Bassolino, Giovanni; Liebel, Matz; Schnedermann, Christoph; Fletcher, Stephen P.; Kukura, Philipp
Journal of the American Chemical Society, 2012 , vol. 134, # 20 p. 8318 - 8320
反应条件
1: 80 percent / NaH
2: 96 percent / HF; pyridine
3: 54 percent / (BrC6H4)3NSbCl6 / CH2Cl2 / 2 h / 20 °C
4: lutidine
5: DIBAL-H
6: NaOMe
7: Dowex 50W-X8 (H+)
8: 56 percent / NaOMe
9: 54 percent / TBAF; AcOH / 50 °C
View Scheme
参考文献
Yamano, Yumiko; Ito, Masayoshi
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 6 p. 780 - 782
反应条件
1.1: n-BuLi; N,N'-dimethylpropyleneurea / hexane; tetrahydrofuran / 0.33 h / 0 °C
1.2: 92 percent / hexane; tetrahydrofuran / 0.5 h / 0 °C
2.1: diisobutylaluminum hydride / hexane; CH2Cl2 / 0.25 h / 0 °C
2.2: 82 percent / SiO2-H2O / hexane; CH2Cl2
View Scheme
参考文献
Wang, Xiao-Feng; Koyama, Yasushi; Nagae, Hiroyoshi; Yamano, Yumiko; Ito, Masayoshi; Wada, Yuji
Chemical Physics Letters, 2006 , vol. 420, # 4-6 p. 309 - 315
