1.1: hydrogen / palladium on activated carbon / methanol / 50 °C / 2250.23 Torr / Inert atmosphere 1.2: 40 °C 2.1: n-butyllithium / toluene; hexane / -80 - -55 °C / Inert atmosphere 2.3: 1 h / 15 - 20 °C / pH 2 3.1: potassium carbonate / 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride / water; tetrahydrofuran / 32 h / 35 - 45 °C / Inert atmosphere 4.1: thionyl chloride / N,N-dimethyl-formamide / 10 - 20 °C 5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C 5.2: -10 °C View Scheme

1.1: palladium 10 on activated carbon; hydrogen / methanol / 1 h / 25 °C / 760.05 Torr 2.1: iodine; silver sulphate / methanol / 3 h / 25 °C 3.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere 3.2: 3 h / -78 °C / Inert atmosphere View Scheme

1: With hydrogen; palladium on activated charcoal in methanol T=20°C; P=760.051 Torr; 1 h; 2: With iodine; silver sulphate in methanol T=20°C; 3 h;

1.1: palladium 10 on activated carbon; hydrogen / methanol / 1 h / 25 °C / 760.05 Torr 2.1: iodine; silver sulphate / methanol / 3 h / 25 °C 3.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere 3.2: 3 h / -78 °C / Inert atmosphere 4.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; water; benzene / 24 h / Inert atmosphere; Reflux View Scheme

1: With hydrogen; palladium on activated carbon in methanol T=50°C; P=2250.23 Torr; Inert atmosphere; 2: With 1,3-dibromo-5,5-dimethyl-hydantoin in methanol T=40°C;