反应条件
1: n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / 30 h / 23 °C
2: NaI / acetone / 65 h / Heating
3: 1.) Mg, 2.) CuI / 1.) THF, reflux, 3 h, 2.) 30 min, ice bath, 3.) 23 deg C, 30 min
4: tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / 23 °C
5: 68 percent / CrO3, 6 N H2SO4 / acetone / 3.5 h, ice-cold then RT
6: 1.) sodium borohydride, 2.) 5percent HCl / 1.) ethanol, 5 min, 2.) RT
View Scheme
参考文献
Oehlschlager, Allan C.; Wong, John W.; Verigin, Victor G.; Pierce, Harold D.
Journal of Organic Chemistry, 1983 , vol. 48, # 25 p. 5009 - 5017
