D-(-)-alpha-苯甘氨酸合成路线 （共 142 条）
反应条件
1: 81 percent / ZnCl2*OEt2 / tetrahydrofuran / 8 h / 0 °C 2: 1.) HCl 2.) 6N HCl / 1.) methanol 2.) 80 deg C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 110, # 2 p. 651 - 652
反应条件
water T=30°C; 26 h; D-aminoacylase from Streptomyces tuirus IFO 13418;
参考文献
Sugie, Makiko; Suzuki, Hideo
Agricultural and Biological Chemistry, 1980 , vol. 44, # 5 p. 1089 - 1096
反应条件
A. faecalis; immobilised penicillin acylase (EC 3.5.1.11) in water; acetonitrile T=0°C; Enzymatic reaction; Product distributionKinetics; Further Variations:Solventsreusing run;
参考文献
Van Langen, Luuk M.; Oosthoek, Natasja H. P.; Van Rantwijk, Fred; Sheldon, Roger A.
Advanced Synthesis and Catalysis, 2003 , vol. 345, # 6-7 p. 797 - 801
反应条件
trifluoroacetic acid 0.333333 h;
参考文献
Lipkowski, Anrzej W.
Polish Journal of Chemistry, 1981 , vol. 55, # 7/8 p. 1725 - 1727
反应条件
hydrogenchloride in water T=80°C; Yield given;
参考文献
Tetrahedron, , vol. 44, # 17 p. 5487 - 5494
反应条件
1: 78 percent / diethyl ether / 15 h / Ambient temperature 2: 82 percent / diisopropylethylamine / dioxane / 20 h / 50 °C 3: 94 percent / H2 / Pd(OH)2 / methanol / 72 h / 760 Torr / Ambient temperature 4: NaIO4, RuCl3*H2O / acetonitrile; CCl4; H2O / 2 h 5: 1.) 3N HCl, 2.) Dowex 50*8 / 1.) THF, room temperature, 2 h. View Scheme
参考文献
Tetrahedron, , vol. 53, # 4 p. 1411 - 1416
反应条件
1: 82 percent / diisopropylethylamine / dioxane / 20 h / 50 °C 2: 94 percent / H2 / Pd(OH)2 / methanol / 72 h / 760 Torr / Ambient temperature 3: NaIO4, RuCl3*H2O / acetonitrile; CCl4; H2O / 2 h 4: 1.) 3N HCl, 2.) Dowex 50*8 / 1.) THF, room temperature, 2 h. View Scheme
参考文献
Tetrahedron, , vol. 53, # 4 p. 1411 - 1416
反应条件
1: 94 percent / H2 / Pd(OH)2 / methanol / 72 h / 760 Torr / Ambient temperature 2: NaIO4, RuCl3*H2O / acetonitrile; CCl4; H2O / 2 h 3: 1.) 3N HCl, 2.) Dowex 50*8 / 1.) THF, room temperature, 2 h. View Scheme
参考文献
Tetrahedron, , vol. 53, # 4 p. 1411 - 1416
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate 24 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 12, # 1 p. 149 - 155
反应条件
Carbonate buffer; Rhodococcus sp. ATCC 39484 nitrilase pH=10.6; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 15, # 18 p. 2793 - 2796
