D-(-)-alpha-苯甘氨酸合成路线 （共 142 条）
反应条件
hydrogen; palladium on activated charcoal in water; acetic acid P=760 Torr; 3 h;
参考文献
Evans, David A.; Britton, Thomas C.; Ellman, Jonathan A.; Dorow, Roberta L.
Journal of the American Chemical Society, 1990 , vol. 112, # 10 p. 4011 - 4030
反应条件
1: With hydrogenchloride; water T=150°C; 0.166667 h; Inert atmosphereMicrowave irradiation; 2: With ammonium hydroxide in water optical yield given as percent ee;
参考文献
Tetrahedron Asymmetry, , vol. 22, # 12 p. 1274 - 1281
反应条件
1: 1.) diisopropylethylamine, dibutylboryl triflate (n-Bu2BOTf), 2.) N-bromosuccinimide (NBS) / 1.) CH2Cl2, a.) -78 deg C, 15 min, b.) 0 deg C, 1 h, 2.) -78 deg C, 1 h 2: tetramethylguanidinium azide (TMGA) / CH2Cl2 / 1 h / -23 °C 3: 97 percent / lithium hydroxide / tetrahydrofuran; H2O / 0.5 h / 0 °C 4: 97 percent / H2 / 10percent Pd/C / H2O; acetic acid / 3 h / 760 Torr View Scheme
参考文献
Journal of the American Chemical Society, , vol. 112, # 10 p. 4011 - 4030
反应条件
ozone in methanol T=-78°C; 0.25 h;
参考文献
Demir, Ayhan S.; Sesenoglu, Oezge; Uelkue, Dincer; Arici, Cengiz
Helvetica Chimica Acta, 2003 , vol. 86, # 1 p. 91 - 105
反应条件
1: tetramethylguanidinium azide (TMGA) / CH2Cl2 / 1 h / -23 °C 2: 97 percent / lithium hydroxide / tetrahydrofuran; H2O / 0.5 h / 0 °C 3: 97 percent / H2 / 10percent Pd/C / H2O; acetic acid / 3 h / 760 Torr View Scheme
参考文献
Journal of the American Chemical Society, , vol. 112, # 10 p. 4011 - 4030
反应条件
1: 97 percent / lithium hydroxide / tetrahydrofuran; H2O / 0.5 h / 0 °C 2: 97 percent / H2 / 10percent Pd/C / H2O; acetic acid / 3 h / 760 Torr View Scheme
参考文献
Journal of the American Chemical Society, , vol. 112, # 10 p. 4011 - 4030
反应条件
sodium naphthalenide in ethylene glycol dimethyl ether T=-40°C; 0.5 h;
参考文献
Braun, Manfred; Opdenbusch, Kersten
Liebigs Annales, 1997 , # 1 p. 141 - 154
反应条件
(1S)-10-camphorsulfonic acid
参考文献
Journal of the American Chemical Society, , vol. 42, p. 2273
Journal of the Chemical Society, , vol. 127, p. 284
反应条件
potassium tert-butylate in tetrahydrofuran T=0°C; Hydrolysis; 0.25 h;
参考文献
Alezra, Valerie; Bouchet, Celine; Micouin, Laurent; Bonin, Martine; Husson, Henri-Philippe
Tetrahedron Letters, 2000 , vol. 41, # 5 p. 655 - 658
反应条件
hydrogenchloride; C16H15O4S(1-)*K(1+); C15H12ClO4S(1-)*K(1+) in water; isopropyl alcohol Resolution of racemate; Product distribution / selectivity;
参考文献
US6639103 B1, ;
Page/Page column 12-13 ;
