2-氨基-5-溴-3-氟苯甲酸合成路线 （共 3 条）
反应条件
N-bromosuccinmide in dichloromethane
T=20°C; 2 h;
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
Location in patent: Page/Page column 77 ;
反应条件
1: borane-THF / tetrahydrofuran / 0 - 20 °C
2: manganese(IV) oxide / dichloromethane / 20 °C
3: 2 h / 180 °C
4: trichlorophosphate / 5 h / |Reflux
View Scheme
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
反应条件
Multi-step reaction with 3 steps 1: borane-THF / tetrahydrofuran / 0 - 20 °C2: manganese(IV) oxide / dichloromethane / 20 °C3: 2 h / 180 °C
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V. Patent: WO2014/11900 A2, 2014 ;
