3-[4-[4-[4-(2,5-二氧代吡咯烷-3-基)苯氧基]丁氧基]苯基]吡咯烷-2,5-二酮合成路线 （共 4 条）
反应条件
1: 83.1 percent / piperidine, glacial acetic acid / benzene / Heating
2: 2.) NaOH / 1.) water, ethanol, heating, 2 h, 2.) ethylene glycol, heating, 40 h
3: 1.) acetic anhydride, 2.) ammonia / 1.) heating, 6 h, 2.) ethyl acetate, 2 h
4: 1 h / 200 - 220 °C
View Scheme
参考文献
Nesunts, N. S.; Avetisyan, S. A.; Dzhagatspanyan, I. A.; Akopyan, N. E.; Mndzhoyan, O. L.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 7 p. 480 - 484
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 7 p. 801 - 806
反应条件
1: 1.) NaOEt / 1.) ethanol, reflux, 4 h, 2.) reflux, 48 h
2: 83.1 percent / piperidine, glacial acetic acid / benzene / Heating
3: 2.) NaOH / 1.) water, ethanol, heating, 2 h, 2.) ethylene glycol, heating, 40 h
4: 1.) acetic anhydride, 2.) ammonia / 1.) heating, 6 h, 2.) ethyl acetate, 2 h
5: 1 h / 200 - 220 °C
View Scheme
参考文献
Nesunts, N. S.; Avetisyan, S. A.; Dzhagatspanyan, I. A.; Akopyan, N. E.; Mndzhoyan, O. L.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 7 p. 480 - 484
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 7 p. 801 - 806
反应条件
1: 1.) acetic anhydride, 2.) ammonia / 1.) heating, 6 h, 2.) ethyl acetate, 2 h
2: 1 h / 200 - 220 °C
View Scheme
参考文献
Nesunts, N. S.; Avetisyan, S. A.; Dzhagatspanyan, I. A.; Akopyan, N. E.; Mndzhoyan, O. L.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 7 p. 480 - 484
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 7 p. 801 - 806
反应条件
1: 2.) NaOH / 1.) water, ethanol, heating, 2 h, 2.) ethylene glycol, heating, 40 h
2: 1.) acetic anhydride, 2.) ammonia / 1.) heating, 6 h, 2.) ethyl acetate, 2 h
3: 1 h / 200 - 220 °C
View Scheme
参考文献
Nesunts, N. S.; Avetisyan, S. A.; Dzhagatspanyan, I. A.; Akopyan, N. E.; Mndzhoyan, O. L.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 7 p. 480 - 484
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 7 p. 801 - 806
