R-(3)-苄氧基肉豆蔻酸合成路线 （共 14 条）
反应条件
zinc copper; acetic acid
Reduction;
参考文献
Fukase, Koichi; Fukase, Yoshiyuki; Oikawa, Masato; Liu, Wen-Chi; Suda, Yasuo; Kusumoto, Shoichi
Tetrahedron, 1998 , vol. 54, # 16 p. 4033 - 4050
反应条件
potassium hydroxide in methanol
T=80°C; 2.5 h;
参考文献
Diolez, Christian; Sarfati, S. Robert; Szabo, Ladislas
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 57 - 60
参考文献
Igen, Inc.
Patent: US5597573 A1, 1997 ;
Title/Abstract Full Text Show Details
IGEN Incorporated
Patent: US5593969 A1, 1997 ;
反应条件
1: Et3N / tetrahydrofuran / 17 h / 20 °C
2: trimethylsilyl triflate; triethylsilane / CH2Cl2 / 14 h / 20 °C
3: 10.4 g / aq. LiOH / tetrahydrofuran / 6.5 h / Heating
View Scheme
参考文献
Martin, Olivier R.; Zhou, Wei; Wu, Xinfu; Front-Deschamps, Sophie; Moutel, Stephane; Schindl, Katharina; Jeandet, Patricia; Zbaeren, Claude; Bauer, Jacques A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 20 p. 6000 - 6014
反应条件
1: 86 percent / hexamethyldisiloxane; TMSOTf; triethylsilane / tetrahydrofuran / 2 h
2: 72 percent / zinc; 7 / acetic acid / 2 h / 60 °C
View Scheme
参考文献
Santhanam, Balaji; Boons, Geert-Jan
Organic Letters, 2004 , vol. 6, # 19 p. 3333 - 3336
反应条件
1: 86 percent / hexamethyldisiloxane; TMSOTf; triethylsilane / tetrahydrofuran / 2 h
2: 72 percent / zinc; 7 / acetic acid / 2 h / 60 °C
View Scheme
参考文献
Santhanam, Balaji; Boons, Geert-Jan
Organic Letters, 2004 , vol. 6, # 19 p. 3333 - 3336
反应条件
1: 36.0 g / triethylamine / ethyl acetate
2: 99 percent / hexamethyldisiloxane; TMSOTf; triethylsilane / tetrahydrofuran
3: 81 percent / AcOH; zinc-copper couple
View Scheme
参考文献
Fukase, Koichi; Fukase, Yoshiyuki; Oikawa, Masato; Liu, Wen-Chi; Suda, Yasuo; Kusumoto, Shoichi
Tetrahedron, 1998 , vol. 54, # 16 p. 4033 - 4050
反应条件
1: 99 percent / hexamethyldisiloxane; TMSOTf; triethylsilane / tetrahydrofuran
2: 81 percent / AcOH; zinc-copper couple
View Scheme
参考文献
Fukase, Koichi; Fukase, Yoshiyuki; Oikawa, Masato; Liu, Wen-Chi; Suda, Yasuo; Kusumoto, Shoichi
Tetrahedron, 1998 , vol. 54, # 16 p. 4033 - 4050
反应条件
1: 3.5 g / silver oxide, anhydrous calcium sulphate / benzene / 6 h / Ambient temperature
2: 60 percent / aq. KOH / methanol / 2.5 h / 80 °C
View Scheme
参考文献
Diolez, Christian; Sarfati, S. Robert; Szabo, Ladislas
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 57 - 60
反应条件
trifluoroacetic acid in dichloromethane
22 h; Ambient temperature; Yield given;
参考文献
Oikawa, Masato; Kusumoto, Shoichi
Tetrahedron: Asymmetry, 1995 , vol. 6, # 4 p. 961 - 966
