.beta.-丙氨酸, N-[[2-[[[4-(2,5-二氢-5-氧代-1,2,4-噁二唑-3-基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-2-吡啶-,乙酯合成路线 （共 2 条）
反应条件
1: With 1-propanephosphonic acid cyclic anhydride; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; ethyl acetate
T=20°C; 1.5 h;
2: With acetic acid
T=90°C; Product distribution / selectivity;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/71743 A1, 2007 ;
Location in patent: Page/Page column 19 ;
反应条件
1: 1-methyl-2-[N-[4-(1,2,4-oxadiazol-5-one-3-yl)phenyl]-amino-methyl]-benzimidazol-5-yl-carboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide With hydrogen; 10 palladium on activated carbon in ethanol; acetic acid
T=20°C; P=1500.15 Torr;
2: toluene-4-sulfonic acid in ethanol
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/71742 A1, 2007 ;
Location in patent: Page/Page column 25 ;
