2-氯-1-(2-乙氧基乙基)-1H-苯并咪唑合成路线 （共 9 条）
参考文献
Iemura; Kawashima; Fukuda; Ito; Tsukamoto
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1178 - 1183
反应条件
trichlorophosphate
0.5 h; Heating;
参考文献
Iemura; Kawashima; Fukuda; Ito; Tsukamoto
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1178 - 1183
反应条件
1: 2-Chloro-1H-1,3-benzimidazole With sodium hydride in N,N-dimethyl-formamide
deprotonation; 1 h; cooling;
2: 1-ethoxy-2-bromoethane in N,N-dimethyl-formamide
T=20°C; Substitution; 3 h;
参考文献
Nakano, Hiroyuki; Inoue, Tsutomu; Kawasaki, Nobuhide; Miyataka, Hideki; Matsumoto, Hitoshi; Taguchi, Takeo; Inagaki, Naoki; Nagai, Hiroichi; Satoh, Toshio
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 11 p. 1573 - 1578
反应条件
in N-methyl-acetamide; ethyl acetate
参考文献
Hoechst Marion Roussel, Inc.
Patent: US5932571 A1, 1999 ;
US 5932571 A
反应条件
1: Zn; HCl
2: Heating
3: POCl3
View Scheme
参考文献
Goeker, Hakan; Ayhan-Kilcigil, Guelguen; Tuncbilek, Meral; Kus, Canan; Ertan, Rahmiye; Kendi, Engin; Oezbey, Sueheyla; Fort, Merce; Garcia, Celia; Farre, Antonio J.
Heterocycles, 1999 , vol. 51, # 11 p. 2561 - 2573
反应条件
1: 78 percent / 3 h / Heating
2: 77 percent / 10percent aq. NaOH, Zn / ethanol / Heating
3: 69 percent / 5 h / 150 °C
4: 82 percent / POCl3 / 0.5 h / Heating
View Scheme
参考文献
Iemura; Kawashima; Fukuda; Ito; Tsukamoto
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1178 - 1183
反应条件
1: Heating
2: POCl3
View Scheme
参考文献
Goeker, Hakan; Ayhan-Kilcigil, Guelguen; Tuncbilek, Meral; Kus, Canan; Ertan, Rahmiye; Kendi, Engin; Oezbey, Sueheyla; Fort, Merce; Garcia, Celia; Farre, Antonio J.
Heterocycles, 1999 , vol. 51, # 11 p. 2561 - 2573
反应条件
1: 55.5 percent / NaH in oil / dimethylformamide / 30 - 35 °C
2: Zn; HCl
3: Heating
4: POCl3
View Scheme
参考文献
Goeker, Hakan; Ayhan-Kilcigil, Guelguen; Tuncbilek, Meral; Kus, Canan; Ertan, Rahmiye; Kendi, Engin; Oezbey, Sueheyla; Fort, Merce; Garcia, Celia; Farre, Antonio J.
Heterocycles, 1999 , vol. 51, # 11 p. 2561 - 2573
参考文献
Iemura; Kawashima; Fukuda; Ito; Tsukamoto
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1178 - 1183
