4-(叔丁基二甲基甲硅烷基)氧代-1-丁醇合成路线 （共 27 条）
反应条件
iron(III) chloride in methanol T=23°C; 3 h;
参考文献
Yang, Yong-Qing; Cui, Jia-Rong; Zhu, Lin-Gui; Sun, Ya-Ping; Wu, Yikang
Synlett, 2006 , # 8 p. 1260 - 1262
反应条件
1.1: (COCl)2; DMSO; Et3N / CH2Cl2 / 0.83 h / -60 - -20 °C 2.1: NaH / tetrahydrofuran / 0.5 h / -20 °C 2.2: 80 percent / tetrahydrofuran / 0.83 h / -20 - 20 °C 3.1: 84 percent / DIBALH / CH2Cl2; hexane / 0.33 h / -60 °C 4.1: 94 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / -60 - -20 °C View Scheme
参考文献
Mann, Stephane; Carillon, Sophie; Breyne, Olivier; Marquet, Andree
Chemistry (Weinheim an der Bergstrasse, Germany), 2002 , vol. 8, # 2 p. 439 - 450
反应条件
1H-imidazole in N,N-dimethyl-formamide T=20°C;
参考文献
Itoh, Akichika; Kodama, Tomohiro; Masaki, Yukio
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 6 p. 861 - 864
反应条件
1.1: oxalyl chloride; Et3N; DMSO / CH2Cl2 / 0.33 h / -78 - 0 °C
2.1: n-BuLi; HMPA / tetrahydrofuran; hexane / 0.33 h / 0 - 20 °C
2.2: hexane; tetrahydrofuran / 1 h / 20 °C
3.1: 482 mg / PPTS / ethanol / 20 h / 20 °C
View Scheme
参考文献
Kang, Sung Ho; Lee, Sung Bae; Park, Chul Min
Journal of the American Chemical Society, 2003 , vol. 125, # 51 p. 15748 - 15749
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane
T=-78°C; 2 h;
2: 1-(dimethyl-tert-butylsilyloxy)-butan-4-ol in dichloromethane
T=-78°C; 0.333333 h;
3: With triethylamine in dichloromethane
1 h;
参考文献
Beaumier, Francis; Dupuis, Marianne; Spino, Claude; Legault, Claude Y.
Journal of the American Chemical Society, 2012 , vol. 134, # 13 p. 5938 - 5953
反应条件
chlorodimethyl(phenylthio)chloride methanaminium in dichloromethane
T=20°C; Chlorination; 3 h;
参考文献
Gomez; Gellibert; Wagner; Mioskowski
Tetrahedron Letters, 2000 , vol. 41, # 32 p. 6049 - 6052
反应条件
tetrabutylammomium bromide; chlorodimethyl(phenylthio)chloride methanaminium in dichloromethane
T=20°C; Bromination;
参考文献
Gomez; Gellibert; Wagner; Mioskowski
Tetrahedron Letters, 2000 , vol. 41, # 32 p. 6049 - 6052
