5-(3-三氟甲基苯基)-异噁唑-3-羧酸乙酯合成路线 (共 3 条)
反应条件
triethylamine in tetrahydrofuran
T=0 - 20°C;
参考文献
Zablocki, Jeff; Abelman, Matthew; Organ, Michael; Bilokin, Yaroslav; Diamond, Ivan; Arolfo, Maria Pia; Yao, Lina; Fan, Peidong; Elzein, Elfatih; Kalla, Rao; Perry, Thao; Kobayshi, Tetsuya; Lee, Xiaofen; Jiang, Robert
Patent: US2008/32995 A1, 2008 ;
Location in patent: Page/Page column 22 ;
US 20080032995 A1
反应条件
triethylamine in tetrahydrofuran
T=20°C; Cooling with ice;
参考文献
CV THERAPEUTICS, INC.
Patent: WO2009/94028 A1, 2009 ;
Location in patent: Page/Page column 55 ;
WO 2009/094028 A1
反应条件
hydroxylamine in ethanol
2 h; Heating / reflux;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2005/121134 A1, 2005 ;
Location in patent: Page/Page column 58-59 ;