4-氯-3-甲基-1H-吡唑并[3,4-d]嘧啶合成路线 （共 4 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 1 h;
参考文献
US2009/5359 A1, ;
Page/Page column 19 ;
US 20090005359 A1
反应条件
triethylamine; hydrazine in 1,4-dioxane
T=0 - 20°C; 18 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/12635 A2, 2008 ;
Location in patent: Page/Page column 84 ;
反应条件
1: With oxalyl dichloride; N,N-dimethyl-formamide in chloroform
8 h; Heating / reflux;
2: With sodium hydrogencarbonate in chloroform; water
参考文献
EXELIXIS, INC.
Patent: WO2005/117909 A2, 2005 ;
Location in patent: Page/Page column 57 ;
WO 2005/117909 A2
反应条件
triethylamine in 1,4-dioxane
T=8 - 20°C; 2.5 h;
参考文献
Sunesis Pharmaceuticals, Inc
Patent: US2009/5359 A1, 2009 ;
Location in patent: Page/Page column 19 ;
US 20090005359 A1
