2-(苄氧基)-2-甲基丙酸合成路线 （共 9 条）
反应条件
lithium aluminium tetrahydride
参考文献
Lin, Shuqiong; Bondar, Georgiy V.; Levy, Christopher J.; Collins, Scott
Journal of Organic Chemistry, 1998 , vol. 63, # 6 p. 1885 - 1892
反应条件
1: With methanol; sodium hydroxide in tetrahydrofuran
1 h; Reflux;
2: With hydrogenchloride in tetrahydrofuran
pH=2;
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;
Location in patent: Paragraph 0557; 0558 ;
反应条件
sodium hydride in N,N-dimethyl-formamide
T=25°C;
参考文献
Lin, Shuqiong; Bondar, Georgiy V.; Levy, Christopher J.; Collins, Scott
Journal of Organic Chemistry, 1998 , vol. 63, # 6 p. 1885 - 1892
反应条件
sodium hydroxide in methanol
5 h; Ambient temperature;
参考文献
Mori, Yuji; Fujiwara, Shigeru; Miyachi, Toshiko; Kitanishi, Hiroyuki; Oya, Masayuki; et al.
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 5 p. 1505 - 1517
参考文献
Galimberti et al.
Farmaco, Edizione Scientifica, 1959 , vol. 14, p. 54,57
反应条件
potassium hydroxide; water; sodium hydride
1.) mineral oil, 120 - 130 deg C, 6 days, 2.) THF, reflux, 42 h; Yield given. Multistep reaction;
参考文献
Crout, David H. G.; McIntyre, C. Rupert; Alcock, Nathaniel W.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , # 1 p. 53 - 62
反应条件
1: oxalyl chloride
3: 58 percent / 1 weight percent rhodium acetate / CH2Cl2 / Ambient temperature
4: 86 percent / SeO2 / 2-methyl-propan-2-ol / Ambient temperature
View Scheme
参考文献
Adams, Julian; Poupart, Marc-Andre; Grenier, Louis; Schaller, Chris; Ouimet, Nathalie; Frenette, Richard
Tetrahedron Letters, 1989 , vol. 30, # 14 p. 1749 - 1752
反应条件
1: oxalyl chloride
3: 58 percent / 1 weight percent rhodium acetate / CH2Cl2 / Ambient temperature
View Scheme
参考文献
Adams, Julian; Poupart, Marc-Andre; Grenier, Louis; Schaller, Chris; Ouimet, Nathalie; Frenette, Richard
Tetrahedron Letters, 1989 , vol. 30, # 14 p. 1749 - 1752
反应条件
iodine; mercury(II) oxide in tetrachloromethane
5 h; Irradiation; Product distribution;
参考文献
Glover, Stephen A.; Golding, Stephen L.; Goosen, Andre; McCleland, Cedric W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 10 p. 2479 - 2483
