2-氨基-N,3-二甲基苯甲酰胺合成路线 （共 11 条）
反应条件
1: 2-amino-3-methyl benzoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=40°C; 3 h; 2: methylamine in tetrahydrofuran T=20°C; 1 h;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1757594 A1, 2007 ;
Location in patent: Page/Page column 50 ;
EP 1757594 A1
反应条件
acetic acid in water; ethyl acetate T=35 - 37°C; 3.33333 h;
参考文献
E.I. DUPONT DE NEMOURS AND COMPANY
Patent: WO2006/62978 A1, 2006 ;
Location in patent: Page/Page column 24 ;
反应条件
polymethylhydrosiloxane; [Ni(1,5-cyclooctadiene)(1,1'-bis(diphenylphosphino)ferrocene)] in acetonitrile T=70 - 72°C; 3 h; Product distribution / selectivity;
参考文献
E. I. DU PONT DE NEMOURS AND COMPANY
Patent: WO2009/61991 A1, 2009 ;
Location in patent: Page/Page column 40-42 ;
反应条件
in ethanol; toluene T=20 - 30°C; 0.833333 h; Cooling with ice bath;
参考文献
EP1900730 A1, ;
Page/Page column 49 ;
反应条件
sodium carbonate; [(t-Bu)3PH]BF4; zinc; tris-(dibenzylideneacetone)dipalladium(0) in tetrahydrofuran; acetonitrile T=20 - 50°C; 17 h; Product distribution / selectivity;
参考文献
WO2008/70158 A1, ;
Page/Page column 28 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 22 p. 4898 - 4906
反应条件
1.1: EtOCOCl; Et3N / tetrahydrofuran / 10 °C 1.2: tetrahydrofuran 2.1: H2 / Pd/C / ethanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 22 p. 4898 - 4906
反应条件
copper(l) iodide; 2,4-dimethyl-pyridine; methoxybenzene T=155°C; 12 h; Product distribution / selectivity;
参考文献
WO2009/85816 A1, ;
Page/Page column 31-32 ;
参考文献
Feng, Qi; Liu, Zhi-Li; Xiong, Li-Xia; Wang, Ming-Zhong; Li, Yong-Qiang; Li, Zheng-Ming
Journal of Agricultural and Food Chemistry, 2010 , vol. 58, # 23 p. 12327 - 12336
反应条件
1: thionyl chloride / Reflux 2: dichloromethane View Scheme
参考文献
Journal of Agricultural and Food Chemistry, , vol. 58, # 23 p. 12327 - 12336
