2-甲基-4-苯氧基-2-丁醇合成路线 (共 10 条)
参考文献
The Board of Regents for the Oklahoma Agricultural and Mechanical College acting for and on behalf of Oklahoma State University
Patent: US4826984 A1, 1989 ;
反应条件
in tetrahydrofuran; diethyl ether
24 h; Heating;
参考文献
Waugh, Kristy M.; Berlin, K. Darrell; Ford, Warren T.; Holt, Elizabeth M.; Carrol, John P.; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 116 - 124
参考文献
AMGEN INC.
Patent: WO2008/30520 A1, 2008 ;
Location in patent: Page/Page column 158 ;
WO 2008/030520 A1
反应条件
1: 87.1 percent / p-TsOH / 36 h / Heating
2: 76.4 percent / diethyl ether; tetrahydrofuran / 24 h / Heating
View Scheme
参考文献
Waugh, Kristy M.; Berlin, K. Darrell; Ford, Warren T.; Holt, Elizabeth M.; Carrol, John P.; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 116 - 124
反应条件
trifluoromethyl amino ketone in dichloromethane
T=0°C; 0.333333 h; Further byproducts given;
参考文献
Julia, M.; Schmitz, C.
Bulletin de la Societe Chimique de France, 1986 , # 4 p. 630 - 636
参考文献
Julia, M.; Schmitz, C.
Bulletin de la Societe Chimique de France, 1986 , # 4 p. 630 - 636
反应条件
in diethyl ether
24 h; Heating;
参考文献
Dib; Ibrahim; Al-Awadi
International Journal of Chemical Kinetics, 2008 , vol. 40, # 2 p. 51 - 58
反应条件
1: 62 percent / AlCl3 / nitromethane / 24 h / Ambient temperature
2: 76.5 percent / AlCl3 / nitromethane / 6 h / Ambient temperature
View Scheme
参考文献
Waugh, Kristy M.; Berlin, K. Darrell; Ford, Warren T.; Holt, Elizabeth M.; Carrol, John P.; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 116 - 124
反应条件
1: 62 percent / AlCl3 / nitromethane / 24 h / Ambient temperature
2: 76.5 percent / AlCl3 / nitromethane / 6 h / Ambient temperature
3: 59.4 percent / LiAlH4 / diethyl ether / 24 h / Heating
4: 80.3 percent / methanol / 24 h / Ambient temperature
5: 1.) n-BuLi / 1.) ether, hexane, RT, 5 min, 2.) ether, hexane, RT, 36 h
View Scheme
参考文献
Waugh, Kristy M.; Berlin, K. Darrell; Ford, Warren T.; Holt, Elizabeth M.; Carrol, John P.; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 116 - 124
反应条件
bismuth trifluoromethanesulphonate in chloroform
Friedel-Crafts Alkylation; 0.333333 h; Inert atmosphere;
参考文献
Nammalwar, Baskar; Bunce, Richard A.
Tetrahedron Letters, 2013 , vol. 54, # 32 p. 4330 - 4332