(R,S)-N-乙基降烟碱/(R,S)-3-(N-乙基吡咯烷-2-基)吡啶合成路线 （共 6 条）
反应条件
1: With sodium tris(acetoxy)borohydride; acetic acid in tetrahydrofuran; dichloromethane
T=-78 - 20°C;
2: With Amberlyst 15 in tetrahydrofuran; dichloromethane
T=20°C; 1 h;
3: With triethylamine in dichloromethane
T=20°C; 1 h;
参考文献
Baxendale, Ian R.; Brusotti, Gloria; Matsuoka, Masato; Ley, Steven V.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 2 p. 143 - 154
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Braumann, Thomas; Nicolaus, Gerd; Hahn, Wolfgang; Elmenhorst, Hinrich
Phytochemistry (Elsevier), 1990 , vol. 29, # 11 p. 3693 - 3694
反应条件
2: LiAlH4 / diethyl ether
View Scheme
参考文献
Braumann, Thomas; Nicolaus, Gerd; Hahn, Wolfgang; Elmenhorst, Hinrich
Phytochemistry (Elsevier), 1990 , vol. 29, # 11 p. 3693 - 3694
反应条件
1.1: 85 percent / Et3N; 1,3-dichlorocyclohexylcarbodiimide / CH2Cl2 / 20 °C
2.1: Mg / tetrahydrofuran / 1 h / 20 °C
2.2: 77 percent / tetrahydrofuran / -78 - 20 °C
3.1: Amberlyst 15; H2O / acetone / 4 h / 20 °C
3.2: 81 percent / Et3N / CH2Cl2 / 2 h / 20 °C
4.1: sodium triacetoxyborohydride; AcOH / CH2Cl2; tetrahydrofuran / -78 - 20 °C
4.2: Amberlyst 15 / CH2Cl2; tetrahydrofuran / 1 h / 20 °C
4.3: 84 percent / Et3N / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Baxendale, Ian R.; Brusotti, Gloria; Matsuoka, Masato; Ley, Steven V.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 2 p. 143 - 154
反应条件
1.1: Mg / tetrahydrofuran / 1 h / 20 °C
1.2: 77 percent / tetrahydrofuran / -78 - 20 °C
2.1: Amberlyst 15; H2O / acetone / 4 h / 20 °C
2.2: 81 percent / Et3N / CH2Cl2 / 2 h / 20 °C
3.1: sodium triacetoxyborohydride; AcOH / CH2Cl2; tetrahydrofuran / -78 - 20 °C
3.2: Amberlyst 15 / CH2Cl2; tetrahydrofuran / 1 h / 20 °C
3.3: 84 percent / Et3N / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Baxendale, Ian R.; Brusotti, Gloria; Matsuoka, Masato; Ley, Steven V.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 2 p. 143 - 154
反应条件
1.1: Amberlyst 15; H2O / acetone / 4 h / 20 °C
1.2: 81 percent / Et3N / CH2Cl2 / 2 h / 20 °C
2.1: sodium triacetoxyborohydride; AcOH / CH2Cl2; tetrahydrofuran / -78 - 20 °C
2.2: Amberlyst 15 / CH2Cl2; tetrahydrofuran / 1 h / 20 °C
2.3: 84 percent / Et3N / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Baxendale, Ian R.; Brusotti, Gloria; Matsuoka, Masato; Ley, Steven V.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 2 p. 143 - 154
