1: 4-pyridinecarbonitrile With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran T=-78 - 20°C; 2: 3-hydroxy-2,2-dimethylpropanol With acetic acid in tetrahydrofuran T=20°C; 1 h;

cesium fluoride; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane T=60°C; Suzuki-Miyaura cross-coupling; 5 h;