6-溴-1H-吲哚-3-羧酸甲酯合成路线 （共 5 条）
反应条件
in hexanes T=20°C; 0.0333333 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/140183 A1, 2007 ;
Location in patent: Page/Page column 36 ;
反应条件
1: With sodium cyanide T=20°C; 0.0833333 h; 2: With manganese(IV) oxide T=20°C; Inert atmosphere;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/157270 A1, 2008 ;
Location in patent: Page/Page column 102-103 ;
反应条件
in methanol; hexanes T=20°C; 0.0333333 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2009/12125 A1, 2009 ;
Location in patent: Page/Page column 36 ;
反应条件
acetyl chloride T=65°C; Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2009/12125 A1, 2009 ;
Location in patent: Page/Page column 61 ;
反应条件
1.1: trichlorophosphate / 0.5 h / 0 - 8 °C / Inert atmosphere 1.2: 2 h / 0 - 20 °C 2.1: sodium cyanide / 0.08 h / 20 °C 2.2: 20 °C / Inert atmosphere View Scheme
