1: With water; sodium carbonate 2 - 2.5 h; Heating / reflux; 2: With hydrogenchloride in water T=15 - 18°C; 3 h; Heating / reflux; 3: With sodium hydroxide in water T=15 - 20°C; pH=9.75 - 10; Product distribution / selectivity;

1: ethyl (S)-3-(2-aminoethyl)-5-((2-oxooxazolidin-4-yl)methyl)-1H-indole-2-carboxylate hydrochloride With sodium cyanoborohydride; acetic acid in methanol T=10 - 15°C; 2: formaldehyd in methanol; water T=0°C;

1: With sodium cyanoborohydride; sodium carbonate; acetic acid in water T=-5 - 20°C; Esweiler-Clark methylation; pH=7; 2: With sodium carbonate in methanol; water T=0°C; 3: With hydrogenchloride; sodium carbonate more than 3 stages;